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Learn about Prions in Graphics Rich Video Show Full Record 2901
Source: Ottawa Hospital, Public Health Agency of Canada - www.phac-aspc.gc.ca, University of Alberta. Division of Anatomy. Faculty of Medicine and Dentistry Resource Type(s): Audio Visual Materials Searchable Keywords: Chronic wasting disease Prion diseases Prion protein Abstract: From the web site: "The following video provides insight into what a prion protein is, the role prions play in diseases such as mad cow disease and chronic wasting disease, and the issues scientists are facing today as they study the global impact of those diseases". This video was produced for the Alberta Prion Research Institution and works best if viewed within the browser, Mozilla Firefox. The running time is under 4 minutes.
PrioNet Canada - Research Themes & Projects Show Full Record 3544
Source: PrioNet Canada Resource Type(s): Issue Overviews Searchable Keywords: Chronic wasting disease Disease spread Disease transmission Research Abstract: Lists five areas of research that are conducted at PrioNet Canada. These areas include, Bovine Spongiform Encephalopathy, Chronic Wasting Disease, Creutzfeldt-Jakob Disease, Prion Protein Stucture and Function and Prion Disease Risk Management. Under each of these headings, visitors will find links to descriptions about individual projects. From the website " PrioNet Canada's pan-Canadian network of research excellence includes over 58 diverse scientific members, five international collaborators... ![[IMAGE]](images/icons/image.gif "Image File"){kind=icon} A Normal Prion converting to an Abnormal Prion [Illustration] Show Full Record 2055
Source: universe-review.ca Resource Type(s): Illustrations Searchable Keywords: Biological phenomena Prion protein Abstract: An illustration of the differences between normal and abnormal prion configurations
Oregon State University - A Web-Based Prion Lecture Show Full Record 131
Source: Oregon State University - oregonstate.edu Resource Type(s): Issue Overviews, Presentations Searchable Keywords: Chronic wasting disease Etiology Genetic resistance Genetics Species specificity Abstract: Presented as part of the Oregon State University Instructional Sites, this web-based lecture provides an issue overview as well as technical information, links to tables, and diagrams concerning the prion protein. Quicktime and MP3 records of lecture are available from the site's top navigation bar under "Schedule", titled Prions.
Overview of the Prion Theory with Graphic Illustrations Show Full Record 4996
Source: Science Technologies, Wiley Publishers Resource Type(s): Audio Visual Materials, Issue Overviews Searchable Keywords: Disease transmission Prion diseases Prion protein Abstract: Discusses the theory of prions and includes animated images. One image illustrates how scientists confirmed that viruses did not play a role in transmitting prion diseases to healthy individuals. The other image demonstrates how a misfolded prion protein might "infect" other normal proteins.
A General Model of Prion Strains and Their Pathogenicity Show Full Record 3084
Source: Science. 2007 Nov 9;318(5852):930-6. Resource Type(s): Journal (Articles) Searchable Keywords: Pathogenicity Prion diseases Prion protein Abstract: From abstract (online abstract only): Prions are lethal mammalian pathogens composed of aggregated conformational isomers of a host-encoded glycoprotein and which appear to lack nucleic acids. Their unique biology, allied with the public-health risks posed by prion zoonoses such as bovine spongiform encephalopathy, has focused much attention on the molecular basis of prion propagation and the "species barrier" that controls cross-species transmission. Both are intimately linked to understanding ...
Chronic Subclinical Prion Disease Induced by Low-Dose Inoculum Show Full Record 349
Source: Journal of Virology. 2002 March; 76(5): 2510?2517 Resource Type(s): Journal (Articles) Searchable Keywords: Chronic wasting disease Pathogenicity Physiopathology Prion diseases Prion protein Abstract: From abstract (free full-text available): We have compared the transmission characteristics of the two mouse-adapted scrapie isolates, ME7 and Rocky Mountain Laboratory (RML), in tga20 mice. These mice express elevated levels of PrP protein compared to wild-type mice and display a relatively short disease incubation period following intracerebral prion inoculation. Terminal prion disease in tga20 mice induced by ME7 or RML was characterized by a distinct pattern of clinical signs and different i...
Comparison of Abnormal Prion Protein Glycoform Patterns from Transmissible Spongiform Encephalopathy Agent-Infected Deer, Elk, Sheep, and Cattle Show Full Record 353
Source: Journal of Virology. 2002; 76(23): 12365-12368 Resource Type(s): Journal (Articles) Searchable Keywords: Bovine spongiform encephalopathy Cattle Chemistry Chronic wasting disease Comparative studies Immunoblotting Isolation & purification Prion protein Scrapie Sheep Species specificity Abstract: From abstract (free full-text available): Analysis of abnormal prion protein glycoform patterns from chronic wasting disease (CWD)-affected deer and elk, scrapie-affected sheep and cattle, and cattle with bovine spongiform encephalopathy failed to identify patterns capable of reliably distinguishing these transmissible spongiform encephalopathy diseases. However, PrP-res patterns sometimes differed among individual animals, suggesting infection by different or multiple CWD strains in some specie...
Deposition Patterns of Disease-associated Prion Protein in Captive Mule Deer Brains with Chronic Wasting Disease Show Full Record 293
Source: Acta Neuropathologica. 2001; 102(5): 496-500 Resource Type(s): Journal (Articles) Searchable Keywords: Analysis aspects Brain Chronic wasting disease Humans Pathology Prion diseases Prion protein Veterinary medicine Abstract: From abstract (online abstract only): Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) in captive and free-ranging cervids in the USA; its origin is obscure. Archival formalin-fixed and paraffin-embedded specimens of 16 captive mule deer brains with CWD were analyzed using immunocytochemistry for the disease-associated prion protein (PrP). The most prominent pattern of PrP deposition were plaque-like structures, a substantial proportion of which were florid plaque...
Detection and survival of prion agents in aquatic environments [online abstract only] Show Full Record 4474
Source: Water Res. 2008 May;42(10-11):2465-72. Epub 2008 Feb 14 Resource Type(s): Journal (Articles) Searchable Keywords: Bovine spongiform encephalopathy Chronic wasting disease Disease detection Disease transmission Prion diseases Scrapie Abstract: From abstract: Environmental contamination is considered a potential mechanism of transmission of prion diseases. Sheep scrapie and cervid chronic wasting diseases (CWD) epizootics are thought to be maintained by natural horizontal transmission through the environment. Here, we describe a method for the detection of prion proteins (PrPres) in aquatic environments. The procedure is based on a glycine buffer-mediated extraction, sonication, and an ultracentrifugation step. The detection limit of t... |
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