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Evaluation of Quinacrine Treatment for Prion Diseases Show Full Record 1405
Source: Journal of Virology. 2003 Aug;77(15):8462-9 Resource Type(s): Journal (Articles), Photographs from Slide, Table or Spreadsheet Searchable Keywords: Creutzfeldt-Jakob Syndrome Drug effects Prion diseases Prion protein Quinacrine Therapy Abstract: From abstract (free full-text available): Based on in vitro observations in scrapie-infected neuroblastoma cells, quinacrine has recently been proposed as a treatment for Creutzfeldt-Jakob disease (CJD), including a new variant CJD which is linked to contamination of food by the bovine spongiform encephalopathy (BSE) agent. The present study investigated possible mechanisms of action of quinacrine on prions. The ability of quinacrine to interact with and to reduce the protease resistance of PrP ...
A Short Review of Transmissible Spongiform Encephalopathies, and Guidelines for Managing Risks Associated with Chronic Wasting disease in Captive Cervids in Zoos [Review] Show Full Record 379
Source: Journal of Zoo and Wildlife Medicine. 2003; 34(2): 125-133 Resource Type(s): Journal (Articles) Searchable Keywords: Artiodactyla Chronic wasting disease Deer Disease transmission Epidemiology Humans Kuru Prevention & control Prion diseases Risk factors Scrapie Therapy Zoo Animals Abstract: From abstract (online abstract only): The transmissible spongiform encephalopathies (TSEs) represent an emerging group of diseases that have been labeled as 'prion diseases' because of the recent characterization of the infectious agent. TSEs are caused by prions, which induce neurodegenerative fatal diseases in humans and animals. Some TSEs (scrapie and kuru), have existed in both animals and humans for a very long time, whereas others such as bovine spongiform encephalopathy and variant Creutz...
Prion Diseases and the BSE Crisis Show Full Record 137
Source: Science. 1997 Oct 10; 278 ( 5336) : 245-251 Resource Type(s): Illustrations, Journal (Articles), Photographs from Slide, Table or Spreadsheet Searchable Keywords: Bovine spongiform encephalopathy Cattle Chemistry Creutzfeldt-Jakob Syndrome Disease transmission Etiology Humans Mutations PrPC proteins Therapy Abstract: From abstract (free full-text available): Bovine spongiform encephalopathy (BSE) and human Creutzfeldt-Jakob disease (CJD) are among the most notable central nervous system degenerative disorders caused by prions. CJD may present as a sporadic, genetic, or infectious illness. Prions are transmissible particles that are devoid of nucleic acid and seem to be composed exclusively of a modified protein (PrPSc). The normal, cellular prion protein (PrPC) is converted into PrPSc through a posttranslati...
Viral, Parasitic and Prion Diseases of Farmed Deer and Bison [Review] Show Full Record 366
Source: Revue Scientifique et Technique. 2002 Aug;21(2):219-48 Resource Type(s): Issue Overviews, Journal (Articles) Searchable Keywords: Bison buffalo Captive cervids Chronic wasting disease Deer Diagnosis Epidemiology Parasitic diseases Parasitology Prion diseases Therapy Veterinary medicine Viral diseases Abstract: From abstract (online abstract only): The most important viral disease of farmed deer and bison is malignant catarrhal fever. The other herpesviruses which have been isolated from these species are briefly described. Other viral agents that are recognised in these animals, including adenovirus, parapox, foot and mouth disease, bluetongue, epizootic haemorrhagic disease, bovine virus diarrhoea, rotavirus and coronavirus, are also discussed. Ectoparasites of importance in this group in various par... |
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