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Learn about Prions in Graphics Rich Video Show Full Record 2901
Source: Ottawa Hospital, Public Health Agency of Canada - www.phac-aspc.gc.ca, University of Alberta. Division of Anatomy. Faculty of Medicine and Dentistry Resource Type(s): Audio Visual Materials Searchable Keywords: Chronic wasting disease Prion diseases Prion protein Abstract: From the web site: "The following video provides insight into what a prion protein is, the role prions play in diseases such as mad cow disease and chronic wasting disease, and the issues scientists are facing today as they study the global impact of those diseases". This video was produced for the Alberta Prion Research Institution and works best if viewed within the browser, Mozilla Firefox. The running time is under 4 minutes. ![[IMAGE]](images/icons/image.gif "Image File"){kind=icon} A Normal Prion converting to an Abnormal Prion [Illustration] Show Full Record 2055
Source: universe-review.ca Resource Type(s): Illustrations Searchable Keywords: Biological phenomena Prion protein Abstract: An illustration of the differences between normal and abnormal prion configurations
Deposition Patterns of Disease-associated Prion Protein in Captive Mule Deer Brains with Chronic Wasting Disease Show Full Record 293
Source: Acta Neuropathologica. 2001; 102(5): 496-500 Resource Type(s): Journal (Articles) Searchable Keywords: Analysis aspects Brain Chronic wasting disease Humans Pathology Prion diseases Prion protein Veterinary medicine Abstract: From abstract (online abstract only): Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) in captive and free-ranging cervids in the USA; its origin is obscure. Archival formalin-fixed and paraffin-embedded specimens of 16 captive mule deer brains with CWD were analyzed using immunocytochemistry for the disease-associated prion protein (PrP). The most prominent pattern of PrP deposition were plaque-like structures, a substantial proportion of which were florid plaque...
Scrapie, Chronic Wasting Disease, and Transmissible Mink Encephalopathy Show Full Record 276
Source: Laplanche JL, Hunter N, Shinagawa M, Williams ES. (1999). Scrapie, chronic wasting disease, and transmissible mink encephalopathy. In Prusiner SB. Prion-biology-and-diseases. (pp.393-429). Cold Spring Harbor, NY:Cold Spring Harbor Laboratory Press Resource Type(s): Books Searchable Keywords: Cattle Chemistry Chronic wasting disease Disease transmission Genetics Humans Pathology Prion protein Scrapie Sheep Species specificity Transmissible mink encephalopathy Abstract: Excerpt from web site: Transmissible spongiform encephalopathies (TSE) such as scrapie in sheep and goats, transmissible mink encephalopathy (TME), and chronic wasting disease (CWD) of cervids belong to a group of diseases that affect both humans and animals, known as prion diseases. They are associated with alterations in conformation of a neural cell-surface glycoprotein, the prion protein (PrPC) that aggregates and accumulates in the brain of affected animals or humans. This abnormal form of ...
Subclinical Prion Disease Induced by Oral Inoculation Show Full Record 1859
Source: Journal of Virology. 2003 Jul;77(14):7991-8. Resource Type(s): Journal (Articles), Photographs from Slide Searchable Keywords: Chronic wasting disease Metabolism Pathogenicity Pathology Physiopathology Prion diseases Prion protein PrPC proteins PrPSc proteins Abstract: From abstract (free full-text available): Natural transmission of prion disease is believed to occur by peripheral infection such as oral inoculation. Following this route of inoculation, both the peripheral nervous system and the lymphoreticular system may be involved in the subsequent neuroinvasion of the central nervous system by prions, which may not necessarily result in clinical signs of terminal disease. Subclinical prion disease, characterized by the presence of infectivity and PrPSc in ...
Transmission of Prions from Mule Deer and Elk with Chronic Wasting Disease to Transgenic Mice Expressing Cervid PrP Show Full Record 401
Source: Journal of Virology. 2004 Dec; 78(23): 13345-13350 Resource Type(s): Journal (Articles) Searchable Keywords: Chronic wasting disease Deer Disease transmission Etiology Pathology Physiology Prion protein Abstract: From Abstract(free full-text available): We generated mice expressing cervid prion protein to produce a transgenic system simulating chronic wasting disease (CWD) in deer and elk. While normal mice were resistant to CWD, these transgenic mice uniformly developed signs of neurological dysfunction approximately 230 days following intracerebral inoculation with four CWD isolates. Inoculated transgenic mice homozygous for the transgene array developed disease after approximately 160 days. The brains...
Abnormal Prion Protein in Ectopic Lymphoid Tissue in a Kidney of an Asymptomatic White-tailed Deer Experimentally Inoculated with the Agent of Chronic Wasting Disease. Show Full Record 1300
Source: Veterinary Pathology. 2006 May;43(3):367-9. Resource Type(s): Journal (Articles) Searchable Keywords: Chronic wasting disease Histocytochemistry Kidneys Pathology PrPSc proteins Abstract: From abstract (online abstract only): Chronic wasting disease (CWD), a transmissible spongiform encephalopathy (TSE) of deer and elk, is one of a group of fatal, neurologic diseases that affect several mammalian species, including human beings. Infection by the causative agent induces accumulations of an abnormal form of prion protein (PrPres) in nervous and lymphoid tissues. This report documents the presence of PrPres within ectopic lymphoid follicles in a kidney of a white-tailed deer that ha...
Chronic wasting disease in a Wisconsin white-tailed deer farm Show Full Record 4851
Source: Journal of Veterinary Diagnostic Investigation. 2008 Sep;20(5):698-703. Resource Type(s): Journal (Articles) Searchable Keywords: Animals Chronic wasting disease Deer Epidemiology Pathology Prion diseases Ruminants Wisconsin Abstract: From Abstract: In September 2002, chronic wasting disease (CWD), a prion disorder of captive and wild cervids, was diagnosed in a white-tailed deer (Odocoileus virginianus) from a captive farm in Wisconsin. The facility was subsequently quarantined, and in January 2006 the remaining 76 deer were depopulated. Sixty animals (79%) were found to be positive by immunohistochemical staining for the abnormal prion protein (PrP(CWD)) in at least one tissue; the prevalence of positive staining was high e...
Creutzfeldt-Jakob Disease in Unusually Young Patients Who Consumed Venison Show Full Record 2411
Source: Archives of Neurology. 2001 Oct; 58:1673-1678. Resource Type(s): Journal (Articles) Searchable Keywords: Adverse effects Brain Chronic wasting disease Creutzfeldt-Jakob Disease Deer Disease transmission Genetics Human health Meat Pathology Prion protein United States Abstract: From abstract (free full-text available): Creutzfeldt-Jakob disease (CJD) in humans and chronic wasting disease (CWD) in deer and elk occur in the United States. Recent reports of 3 unusually young patients with CJD who regularly consumed deer or elk meat created concern about the possible zoonotic transmission of CWD. OBJECTIVE: To examine the possible transmission of CWD to humans. PATIENTS: Three unusually young patients (aged 28, 28, and 30 years) with CJD in the United States during 1997-20...
Preclinical Deposition of Pathological Prion Protein PrPSc in Muscles of Hamsters Orally Exposed to Scrapie Show Full Record 2090
Source: Journal of Clinical Investigation. 2004 May;113(10):1465-72. Resource Type(s): Journal (Articles), Photographs from Slide Searchable Keywords: Chronic wasting disease Hamsters Metabolism Pathology PrPSc proteins Scrapie Skeletal muscle Abstract: From abstract (free full-text available): Recently, pathological prion protein PrP(Sc), the putative key constituent of infectious agents causing transmissible spongiform encephalopathies (TSEs), was found in muscles of rodents experimentally infected with scrapie and in patients with Creutzfeldt-Jakob disease (CJD). For the assessment of risk scenarios originating from these findings (e.g., alimentary transmission of pathogens associated with bovine spongiform encephalopathy [BSE] and chronic w... |
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