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[Avian influenza virus] [Review] [Article in Japanese] Show Full Record 755
Source: Uirusu. 2004 Jun;54(1):93-6 Resource Type(s): Journal (Articles) Searchable Keywords: Avian influenza Genetics Pathogenicity Poultry Zoonoses Abstract: ON-LINE ABSTRACT ONLY: Recent outbreaks of highly pathogenic avian influenza in chickens and ducks that occurred in 9 Asian countries including Japan alarmed to realize that there is no border for infections and gave a rise to great concern for human health as well as for agriculture. This H5N1 virus jumped the species barrier and caused severe disease with high mortality in humans in Viet Nam and Thailand; 15 deaths of 22 cases and 8 of 12, respectively. A second concern was the possibility tha...
A Multiplex RT-PCR for Detection of Type A influenza Virus and Differentiation of Avian H5, H7, and H9 Hemagglutinin Subtypes Show Full Record 1293
Source: Molecular and Cellular Probes. 2006 Mar 14; [Epub ahead of print] Resource Type(s): Journal (Articles) Searchable Keywords: Avian influenza Diagnosis Genetics Hemagglutinins Polymerase chain reaction Viral subtypes Abstract: From abstract (online abstract only): A multiplex reverse transcriptase-polymerase chain reaction (mRT-PCR) was developed and optimized for the detection of type A influenza virus; the assay simultaneously differentiates avian H5, H7 and H9 hemagglutinin subtypes. Four sets of specific oligonucleotide primers were used in this test for type A influenza virus, H5, H7 and H9 heamagglutinin subtypes. The mRT-PCR DNA products were visualized by gel electrophoresis and consisted of fragments of 860bp...
A Simple Restriction Fragment Length Polymorphism-based Strategy that Can Distinguish the Internal Genes of Human H1N1, H3N2, and H5N1 Influenza A Viruses Show Full Record 1563
Source: Journal of Clinical Microbiology. 2000 Jul;38(7):2579-83 Resource Type(s): Journal (Articles) Searchable Keywords: Animals Avian influenza Genes Genetics Hong Kong Humans Influenza A Virus Influenza A Virus, H5N1Subtype Outbreaks Virology Abstract: From abstract (free full-text available): A simple molecular technique for rapid genotyping was developed to monitor the internal gene composition of currently circulating influenza A viruses. Sequence information from recent H1N1, H3N2, and H5N1 human virus isolates was used to identify conserved regions within each internal gene, and gene-specific PCR primers capable of amplifying all three virus subtypes were designed. Subtyping was based on subtype-specific restriction fragment length polymo...
A Two-Amino Acid Change in the Hemagglutinin of the 1918 Influenza Virus Abolishes Transmission Show Full Record 2003
Source: Science 2007 Feb 2;315(5812):655-9. Resource Type(s): Journal (Articles) Searchable Keywords: Amino acid substitution Avian influenza Disease transmission Dogs Ferrets Genetics Human Influenza Influenza A Virus, H1N1 Subtype Mutation Viral hemagglutinins Virology Virulence Abstract: From abstract (online abstract only): The 1918 influenza pandemic was a catastrophic series of virus outbreaks that spread across the globe. Here, we show that only a modest change in the 1918 influenza hemagglutinin receptor binding site alters the transmissibility of this pandemic virus. Two amino acid mutations that cause a switch in receptor binding preference from the human alpha-2,6 to the avian alpha-2,3 sialic acid resulted in a virus incapable of respiratory droplet transmission between...
A Virus Reveals Population Structure and Recent Demographic History of its Carnivore Host Show Full Record 1913
Source: Science. 2006 Jan 27;311(5760):538-41. Resource Type(s): Journal (Articles) Searchable Keywords: Alberta Animals Avian influenza Bayes Theorem British Columbia Ecosystem Genes Genetics Geography Molecular evolution Molecular structure Montana Phylogeny Population dynamics Time factors Veterinary medicine Wyoming Abstract: From abstract (online abstract only): Directly transmitted parasites often provide substantial information about the temporal and spatial characteristics of host-to-host contact. Here, we demonstrate that a fast-evolving virus (feline immunodeficiency virus, FIV) can reveal details of the contemporary population structure and recent demographic history of its natural wildlife host (Puma concolor) that were not apparent from host genetic data and would be impossible to obtain by other means. We s...
Alarms Ring Over Bird Flu Mutations Show Full Record 1655
Source: Nature. 2006 Jan 19;439(7074):248-9 Resource Type(s): Journal (Articles) Searchable Keywords: Animals Avian influenza Birds Disease transmission DNA Genetics Humans Influenza A Virus Influenza A Virus, H5N1Subtype Influenza in birds Mutations Pathogenicity Turkey Viral hemagglutinins Virology Virus receptors Virus replication Zoonoses Abstract: No abstract available.
Amplification of the Entire Genome of Influenza A Virus H1N1 and H3N2 Subtypes by Reverse-transcription Polymerase Chain Reaction Show Full Record 1443
Source: Journal of Virological Methods. 2006 Sep;136(1-2):38-43. Epub 2006 May 9. Resource Type(s): Journal (Articles) Searchable Keywords: Avian influenza Genetics Genome Humans Influenza A Virus, H1N1 Subtype Influenza A Virus, H2N2 subtype Methods Reverse transcriptase polymerase chain reaction Abstract: From abstract (online abstract only): This study describes the development of a simple RT-PCR method to amplify the whole genome of the influenza A virus based on the amplification of full-length gene segments. Primers were designed based on the conserved regions of both the 5'-end and the 3'-end of each gene segment. After optimizing the duration and temperature of denaturing, annealing, and extension, these primers could amplify all of the full-length gene segments. To test the accuracy of the...
An Arg-Lys Insertion at the Hemagglutinin Cleavage Site of an H5N2 Avian Influenza Isolate Show Full Record 778
Source: Virus Genes. 1996;12(1):77-84. Resource Type(s): Journal (Articles) Searchable Keywords: Avian influenza Genetics Hemagglutinins Influenza A Virus, H5N2 subtype Abstract: From abstract (online abstract only): Recent isolations of H5N2 subtype avian influenza (AI) viruses in North America have raised questions concerning their origin, transmission to commercial poultry, and potential for virulence. One ratite-origin isolate of low pathogenicity, A/emu/TX/39924/93 (H5N2), was subjected to a procedure that rapidly selects and/or amplifies highly pathogenic (HP) strains. The resulting highly virulent derivative had an altered hemagglutinin (HA) gene containing an add...
An Emerging Avian Influenza A Virus H5N7 Is a Genetic Reassortant of Highly Pathogenic Genes Show Full Record 1541
Source: Vaccine. 2006 Jun 6; [Epub ahead of print] Resource Type(s): Journal (Articles) Searchable Keywords: Avian influenza Genes Genetics Genome Neuraminidase Virology Abstract: From abstract (online abstract only): We full genome characterised the newly discovered avian influenza virus H5N7 subtype combination isolated from a stock of Danish game ducks to investigate the composition of the genome and possible features of high pathogenicity. It was found that the haemagglutinin and the acidic polymerase genes were closely related to a low pathogenic H5 strain (A/Duck/Denmark/65047/04 H5N2). The neuraminidase and the non-structural genes were closely related to the highl...
An Influenza A (H1N1) Virus, Closely Related to Swine Influenza Virus, Responsible for a Fatal Case of Human Influenza [Case Reports] Show Full Record 786
Source: Journal of Virology. 1994 Apr;68(4):2051-8. Resource Type(s): Journal (Articles) Searchable Keywords: Avian influenza Comparative studies Genetics Human Influenza Influenza A Virus Influenza A Virus, H5N1Subtype Maryland Microbiology Swine Abstract: From abstract (free full-text available): In July 1991, an influenza A virus, designated A/Maryland/12/91 (A/MD), was isolated from the bronchial secretions of a 27-year-old animal caretaker. He had been admitted to the hospital with bilateral pneumonia and died of acute respiratory distress syndrome 13 days later. Antigenic analyses with postinfection ferret antisera and monoclonal antibodies to recent H1 swine hemagglutinins indicated that the hemagglutinin of this virus was antigenically rela... |
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