Interactions and Conversions of Prion Protein IsoformsShow Full Record325
Source:
In Caughey B. Prion Protein (pp.139-169). San Diego: Academic Press
Resource Type(s):
Books
Searchable Keywords:
AnimalsChemistryChronic wasting diseaseEpidemiologyHumansIsoform
PathogenicityPrevention & controlProtein folding
Abstract:
From introduction: The odd properties of the infectious agents of the transmissible spongiform encephalopathies (TSE or prion diseases) evoked proposals that they might represent a distinct class of infectious agents (often called prions), which are proteinaceous and devoid of nucleic acid (Griffith, 1967; Prusiner, 1982; Bolton and Bendheim, 1988; Prusiner, 1998). A key ingredient to these proposals is that the infectious agent is
an abnormal form of a host-encoded protein that can interact wit...