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A novel erythroid-specific marker of transmissible spongiform encephalopathies Show Full Record 296
Source: Nature Medicine. 2001; 7(3): 361-364 Resource Type(s): Journal (Articles) Searchable Keywords: Biological markers Chronic wasting disease Diagnosis Mice Prion diseases Abstract: From abstract(free full-text available): Transmissible spongiform encephalopathies (TSE) are a group of invariably fatal neurodegenerative diseases and include scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease in deer and elk, and Kuru disease, Creutzfeldt-Jakob disease (CJD) and variant CJD in humans. The pathological effects of disease occur predominantly in the CNS (central nervous system), where common hallmarks include vacuolation, gliosis, accumula...
A One-Size-Fits-All Flu Vaccine? Show Full Record 1911
Source: Science. 2006 Apr 21;312(5772):380-2. Resource Type(s): Journal (Articles) Searchable Keywords: Animals Antibodies Antigenic variation Avian influenza Clinical trials Hemagglutinins Humans Immunology Influenza A Virus Mice Nucleoproteins Orthomyxoviridae infections Prevention & control Proteins RNA Vaccines Abstract: No abstract available.
Avian Influenza Viruses in Korean Live Poultry Markets and their Pathogenic Potential Show Full Record 1856
Source: Virology. 2005 Feb 20;332(2):529-37. Resource Type(s): Journal (Articles) Searchable Keywords: Amino acid sequence Animals Avian influenza Chickens Influenza A Virus Korea Mice Molecular sequence data Pathogenicity Phylogeny Poultry Rodent diseases Viral proteins Virology Abstract: From abstract (online abstract only): We surveyed live-poultry markets in Korea in 2003 and isolated 9 H9N2, 6 H3N2, and 1 H6N1 influenza viruses. Antigenic and phylogenetic analyses showed that all 9 H9N2 isolates were of A/Chicken/Korea/25232-96006/96-like lineage (which caused disease in chickens in Korea in 1996) but were different from H9N2 viruses of southeastern China. They had at least 4 genotypes and replicated in chickens but not in mice. The H3N2 and H6N1 viruses were new to Korea and...
Avian Influenza. Potentially More Lethal Variant Hits Migratory Birds in China Show Full Record 1072
Source: Science. 2005 Jul 8;309(5732):231 Resource Type(s): Journal (Articles) Searchable Keywords: China Epidemiology Genetic diversity Genetics Humans Influenza A Virus Influenza in birds Mice Migratory birds Outbreaks Pathogenicity Virology Abstract: No abstract available.
Characterization of a Human H5N1 Influenza A Virus Isolated in 2003 Show Full Record 1680
Source: Journal of Virology. 2005 Aug;79(15):9926-32. Resource Type(s): Journal (Articles) Searchable Keywords: Animals Avian influenza Chickens China Comparative studies Ducks Ferrets Humans Influenza A Virus, H5N1Subtype Mice Molecular structure Outbreaks Physiology Poultry diseases Species specificity Veterinary medicine Virulence Virus cultivation Virus receptors Abstract: From abstract (free full-text available): In 2003, H5N1 avian influenza virus infections were diagnosed in two Hong Kong residents who had visited the Fujian province in mainland China, affording us the opportunity to characterize one of the viral isolates, A/Hong Kong/213/03 (HK213; H5N1). In contrast to H5N1 viruses isolated from humans during the 1997 outbreak in Hong Kong, HK213 retained several features of aquatic bird viruses, including the lack of a deletion in the neuraminidase stalk and...
Characterization of Avian H5N1 Influenza Viruses from Poultry in Hong Kong Show Full Record 1149
Source: Virology. 1998 Dec 20;252(2):331-42 Resource Type(s): Journal (Articles) Searchable Keywords: Ducks Feces Geese Hong Kong Humans Influenza A Virus Influenza A Virus, H5N1Subtype Influenza in birds Mice Poultry Poultry diseases Turkeys Viral antibodies Virus replication Zoonoses Abstract: From abstract (online abstract only): The transmission of avian H5N1 influenza viruses to 18 humans in Hong Kong in 1997 with six deaths established that avian influenza viruses can transmit to and cause lethal infection in humans. This report characterizes the antigenic and biological properties of the H5N1 influenza viruses isolated from chickens, ducks, and geese from farms and poultry markets in Hong Kong during 1997 and compares them with those of virus isolated from the index human case. E...
Characterization of the Pathogenicity of Members of the Newly Established H9N2 Influenza Virus Lineages in Asia Show Full Record 984
Source: Virology. 2000 Feb 15;267(2):279-88 Resource Type(s): Journal (Articles) Searchable Keywords: Mice Molecular structure Poultry diseases Viral DNA Viral hemagglutinins Viral RNA Virus replication Abstract: From abstract (online abstract only): The reported transmission of avian H9N2 influenza viruses to humans and the isolation of these viruses from Hong Kong poultry markets lend urgency to studies of their ecology and pathogenicity. We found that H9N2 viruses from North America differ from those of Asia. The North American viruses, which infect primarily domestic turkeys, replicated poorly in inoculated chickens. Phylogenetic analysis of the hemagglutinin and nucleoprotein genes indicated that th...
Consistent Occurrence of Hemagglutinin Variants Among Avian Influenza Virus Isolates of the H7 Subtype Show Full Record 1864
Source: Virus Research. 1994 Oct;34(1):15-29. Resource Type(s): Journal (Articles) Searchable Keywords: Animals Antibodies Avian influenza Chick embryo Chickens Comparative studies Genes Genetics Glycosylation Hemagglutinins Influenza A Virus Mice RNA Viral proteins Abstract: From abstract (online abstract only): Several field isolates of avian influenza virus of the H7 subtype were analyzed for the presence of hemagglutinin variants by labeling proteins in cells infected with virus clones, and reacting with monoclonal antibodies. Each strain was shown to contain two distinct electrophoretic variants of the uncleaved hemagglutinin. In the A/Tk/Ore/71 (H7N3) isolate, two variants remained in the population through 35 laboratory passages, indicating both are stable and...
Distinct Pathogenesis of Hong Kong-origin H5N1 Viruses in Mice Compared to That of Other Highly Pathogenic H5 Avian Influenza Viruses Show Full Record 770
Source: Journal of Virology. 2000 Feb;74(3):1443-50. Resource Type(s): Journal (Articles) Searchable Keywords: Avian influenza Comparative studies Hong Kong Humans Influenza A Virus Influenza A Virus, H5N1Subtype Mice Microbiology Pathogenicity Virology Abstract: From abstract (free full-text available): In 1997, an outbreak of virulent H5N1 avian influenza virus occurred in poultry in Hong Kong (HK) and was linked to a direct transmission to humans. The factors associated with transmission of avian influenza virus to mammals are not fully understood, and the potential risk of other highly virulent avian influenza A viruses infecting and causing disease in mammals is not known. In this study, two avian and one human HK-origin H5N1 virus along with four a...
Enhanced Virulence of Influenza A Viruses with the Haemagglutinin of the 1918 Pandemic Virus [Letter] Show Full Record 1941
Source: Nature. 2004 Oct 7;431(7009):703-7. Resource Type(s): Journal (Articles) Searchable Keywords: Animals Antibodies Avian influenza Dogs Epidemiology Genes Genetic recombination Hemagglutinins Humans Immune sera Influenza A Virus Metabolism Mice Neuraminidase Pathogenicity Time factors Virology Virulence Abstract: From abstract (online abstract only): The 'Spanish' influenza pandemic of 1918-19 was the most devastating outbreak of infectious disease in recorded history. At least 20 million people died from their illness, which was characterized by an unusually severe and rapid clinical course. The complete sequencing of several genes of the 1918 influenza virus has made it possible to study the functions of the proteins encoded by these genes in viruses generated by reverse genetics, a technique that perm... |
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