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A Common Surface Antigen in Influenza Viruses from Human and Avian Sources Show Full Record 1901
Source: Journal of General Virology. 1968 Sep;3(2):201-8. Resource Type(s): Journal (Articles) Searchable Keywords: Analysis aspects Antigens Avian influenza Hemagglutinins Humans Immunology Neuraminidase Orthomyxoviridae Species specificity Abstract: No abstract available.
An Emerging Avian Influenza A Virus H5N7 Is a Genetic Reassortant of Highly Pathogenic Genes Show Full Record 1541
Source: Vaccine. 2006 Jun 6; [Epub ahead of print] Resource Type(s): Journal (Articles) Searchable Keywords: Avian influenza Genes Genetics Genome Neuraminidase Virology Abstract: From abstract (online abstract only): We full genome characterised the newly discovered avian influenza virus H5N7 subtype combination isolated from a stock of Danish game ducks to investigate the composition of the genome and possible features of high pathogenicity. It was found that the haemagglutinin and the acidic polymerase genes were closely related to a low pathogenic H5 strain (A/Duck/Denmark/65047/04 H5N2). The neuraminidase and the non-structural genes were closely related to the highl... ![[PDF]](images/icons/pdf.gif "Adobe Reader File"){kind=icon} Antibodies to Human Influenzavirus Neuraminidase (the A-Asian-57 H2N2 Strain) in Sera from Australian Pelagic Birds Show Full Record 1457
Source: Bulletin of the World Health Organization. 1972;47(4):535-41 Resource Type(s): Journal (Articles) Searchable Keywords: Analysis aspects Animals Antibodies Australia Avian influenza Bird diseases Birds Human Influenza Humans Immunology Microbiology Neuraminidase Orthomyxoviridae Serology Veterinary medicine Abstract: From abstract (free full-text available): Sera collected from Australian pelagic birds specifically inhibited the neuraminidase of the Asian/57 (H2N2) strain of human influenzavirus. Neuraminidase inhibition titres of some sera were high and the avidity of the inhibitor was comparable to that of specific antibody. The neuraminidase of A/Hong Kong/1/68 (H3N2), which was undergone considerable antigenic drift in man since 1957, was inhibited to a lesser extent by the bird sera, while the neuramini...
Avian Flu Special: What's in the Medicine Cabinet? Show Full Record 1524
Source: Nature. 2005 May 26;435(7041):407-9 Resource Type(s): Journal (Articles) Searchable Keywords: Animals Antiviral agents Avian influenza Enzymology Humans International policy Neuraminidase Orthomyxoviridae World Health Organization Abstract: No abstract available. Avian Influenza Surveys in Waterfowl Part I: The Role of Wild and Domestic Waterfowl in Avian Influenza Outbreaks in Domestic Poultry Show Full Record 1261
Source: National Animal Health Surveillance System (NAHSS) Outlook. 2005 Feb; Issue 4. Resource Type(s): Newsletters/Bulletins Searchable Keywords: Avian influenza Birds Ducks Epidemiology Isolation & purification Neuraminidase Turkeys Vertical transmission (disease) Viral hemagglutinins Virology Abstract: From introduction (free full-text available): It is generally accepted that waterfowl play an important role in the generation, spread, and enzootic transmission of avian influenza (AI). Published surveys indicate that all 15 hemagglutinin (HA) and 9 neuraminidase (NA) subtypes have been isolated from wild waterfowl and aquatic shorebirds. Reported overall prevalence estimates vary considerably between studies and study years. For example, recently cited overall AI prevalence rates in waterfowl ...
Changes in the Haemagglutinin and the Neuraminidase Genes Prior to the Emergence of Highly Pathogenic H7N1 Avian Influenza Viruses in Italy Show Full Record 1519
Source: Archives of Virology. 2001;146(5):963-73 Resource Type(s): Journal (Articles) Searchable Keywords: Amino acid sequence Animals Avian influenza Birds Chickens Comparative studies Genes Genetics Hemagglutinins Influenza A Virus Influenza in birds Italy Molecular structure Neuraminidase Outbreaks Poultry diseases Proteins Turkeys Virology Abstract: From abstract (online abstract only): Outbreaks of avian influenza due to an H7N1 virus of low pathogenicity occurred in domestic poultry in northern Italy from March 1999 until December 1999 when a highly pathogenic avian influenza (HPAI) virus emerged. Nucleotide sequences were determined for the HA1 and the stalk region of the neuraminidase (NA) for viruses from the outbreaks. The HPAI viruses have an unusual multibasic haemagglutinin (HA) cleavage site motif, PEIPKGSRVRRGLF. Phylogenetic ana...
Characterization of an Avian Influenza A (H5N1) Virus Isolated from a Child with a Fatal Respiratory Illness Show Full Record 1463
Source: Science. 1998 Jan 16;279(5349):393-6 Resource Type(s): Journal (Articles) Searchable Keywords: Amino acid sequence Animals Avian influenza Cell lines Chickens Genes Genetics Hemagglutinins Hong Kong Humans Influenza A Virus Influenza in birds Molecular structure Neuraminidase Outbreaks Pathogenicity Virology Virus replication Abstract: From abstract (free full-text available): An avian H5N1 influenza A virus (A/Hong Kong/156/97) was isolated from a tracheal aspirate obtained from a 3-year-old child in Hong Kong with a fatal illness consistent with influenza. Serologic analysis indicated the presence of an H5 hemagglutinin. All eight RNA segments were derived from an avian influenza A virus. The hemagglutinin contained multiple basic amino acids adjacent to the cleavage site, a feature characteristic of highly pathogenic avian ...
Characterization of the Hemagglutinin and Neuraminidase Genes of Recent Influenza Virus Isolates from Different Avian Species in Thailand. Show Full Record 1254
Source: Acta virologica. 2005;49(4):277-80. Resource Type(s): Journal (Articles) Searchable Keywords: Avian influenza Chickens Hemagglutinins Influenza A Virus Influenza A Virus, H5N1Subtype Neuraminidase Thailand Abstract: From abstract (online abstract only): The hemagglutinin (HA) and neuraminidase (NA) genes of eight influenza A virus (H5N1) isolates obtained from various avian species in Thailand in 2003-2004 have been characterized in comparison with the Thai isolate A/Chicken/Nakorn-Pathom/Thailand/CU-K2/04(H5N1). Phylogenetic analyses of both genes revealed that all the eight avian isolates were closely related to the A/Chicken/Nakorn-Pathom/Thailand/CU-K2/ 04(H5N1). The amino acid sequence of the HA cleava...
Characterization of the Surface Proteins of Influenza A (H5N1) Viruses Isolated from Humans in 1997-1998 Show Full Record 1521
Source: Virology. 1999 Feb 1;254(1):115-23 Resource Type(s): Journal (Articles) Searchable Keywords: Antigens Avian influenza DNA Genes Genetics Hemagglutinins Hong Kong Humans Influenza A Virus Influenza A Virus, H5N1Subtype Molecular structure Neuraminidase Outbreaks Virology Abstract: From abstract (online abstract only): Influenza A (H5N1) viruses infected humans in Hong Kong between May and December, 1997. Sixteen viruses, including 6 from fatal cases, were isolated during this outbreak. Molecular analysis of the surface proteins genes encoding the hemagglutinin (HA) and neuraminidase (NA) of these H5N1 isolates, of a subtype not previously known to infect humans, are presented. The 16 human H5 HA sequences contain multiple basic amino acids adjacent to the cleavage site, a...
Emergence of Drug-Resistant Influenza Virus: Population Dynamical Considerations Show Full Record 1910
Source: Science. 2006 Apr 21;312(5772):389-91. Resource Type(s): Journal (Articles) Searchable Keywords: Antiviral agents Avian influenza Computer simulation Drug resistance Humans Influenza A Virus Mutation Neuraminidase Orthomyxoviridae Outbreaks Population dynamics Prevention & control Therapy Abstract: From abstract (online abstract only): Given the considerable challenges to the rapid development of an effective vaccine against influenza, antiviral agents will play an important role as a first-line defense if a new pandemic occurs. The large-scale use of drugs for chemoprophylaxis and treatment will impose strong selection for the evolution of drug-resistant strains. The ensuing transmission of those strains could substantially limit the effectiveness of the drugs as a first-line defense. Sum... |
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