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A One-Size-Fits-All Flu Vaccine? Show Full Record 1911
Source: Science. 2006 Apr 21;312(5772):380-2. Resource Type(s): Journal (Articles) Searchable Keywords: Animals Antibodies Antigenic variation Avian influenza Clinical trials Hemagglutinins Humans Immunology Influenza A Virus Mice Nucleoproteins Orthomyxoviridae infections Prevention & control Proteins RNA Vaccines Abstract: No abstract available.
Changes in the Haemagglutinin and the Neuraminidase Genes Prior to the Emergence of Highly Pathogenic H7N1 Avian Influenza Viruses in Italy Show Full Record 1519
Source: Archives of Virology. 2001;146(5):963-73 Resource Type(s): Journal (Articles) Searchable Keywords: Amino acid sequence Animals Avian influenza Birds Chickens Comparative studies Genes Genetics Hemagglutinins Influenza A Virus Influenza in birds Italy Molecular structure Neuraminidase Outbreaks Poultry diseases Proteins Turkeys Virology Abstract: From abstract (online abstract only): Outbreaks of avian influenza due to an H7N1 virus of low pathogenicity occurred in domestic poultry in northern Italy from March 1999 until December 1999 when a highly pathogenic avian influenza (HPAI) virus emerged. Nucleotide sequences were determined for the HA1 and the stalk region of the neuraminidase (NA) for viruses from the outbreaks. The HPAI viruses have an unusual multibasic haemagglutinin (HA) cleavage site motif, PEIPKGSRVRRGLF. Phylogenetic ana...
Early Diagnosis of Avian Influenza Show Full Record 1922
Source: Science. 2006 Apr 21;312(5772):337. Resource Type(s): Journal (Articles) Searchable Keywords: Animals Avian influenza Birds Diagnosis Humans Influenza A Virus Influenza in birds Proteins Sensitivity and specificity Abstract: No abstract available (free full-text available).
Evolution of Influenza A Virus Nucleoprotein Genes: Implications for the Origins of H1N1 Human and Classical Swine Viruses Show Full Record 1875
Source: Journal of Virology. 1991 Jul;65(7):3704-14. Resource Type(s): Journal (Articles) Searchable Keywords: Amino acid sequence Animals Avian influenza Cloning Comparative studies Evolution Genetics Influenza A Virus Influenza A Virus, H1N1 Subtype Molecular structure Proteins Abstract: From abstract (free full-text available): A phylogenetic analysis of 52 published and 37 new nucleoprotein (NP) gene sequences addressed the evolution and origin of human and swine influenza A viruses. H1N1 human and classical swine viruses (i.e., those related to Swine/Iowa/15/30) share a single common ancestor, which was estimated to have occurred in 1912 to 1913. From this common ancestor, human and classical swine virus NP genes have evolved at similar rates that are higher than in avian vir...
Genetic Characterization of H5N1 Influenza A Viruses Isolated from Zoo Tigers in Thailand Show Full Record 1516
Source: Virology. 2006 Jan 20;344(2):480-91. Epub 2005 Sep 27 Resource Type(s): Journal (Articles) Searchable Keywords: Amino acid sequence Animals Avian influenza Genetics Humans Influenza A Virus, H5N1Subtype Isolation & purification Orthomyxoviridae infections Outbreaks Proteins Thailand Tigers Virology Zoo Animals Abstract: From abstract (online abstract only): The H5N1 avian influenza virus outbreak among zoo tigers in mid-October 2004, with 45 animals dead, indicated that the avian influenza virus could cause lethal infection in a large mammalian species apart from humans. In this outbreak investigation, six H5N1 isolates were identified and two isolates (A/Tiger/Thailand/CU-T3/04 and A/Tiger/Thailand/CU-T7/04) were selected for whole genome analysis. Phylogenetic analysis of the 8 gene segments showed that the v...
Influenza B Virus in Seals Show Full Record 1917
Source: Science. 2000 May 12;288(5468):1051-3. Resource Type(s): Journal (Articles) Searchable Keywords: Animals Antibodies Avian influenza Disease reservoirs Dogs Genes Hemagglutinins Humans Influenza B Virus Isolation & purification Orthomyxoviridae infections Proteins Seals Veterinary medicine Virology Virus shedding Abstract: From abstract (online abstract only): Influenza B virus is a human pathogen whose origin and possible reservoir in nature are not known. An influenza B virus was isolated from a naturally infected harbor seal (Phoca vitulina) and was found to be infectious to seal kidney cells in vitro. Sequence analyses and serology indicated that influenza virus B/Seal/Netherlands/1/99 is closely related to strains that circulated in humans 4 to 5 years earlier. Retrospective analyses of sera collected from 97...
Molecular Basis for High Virulence of Hong Kong H5N1 Influenza A Viruses Show Full Record 1926
Source: Science. 2001 Sep 7;293(5536):1840-2. Resource Type(s): Journal (Articles) Searchable Keywords: Amino acid sequence Animals Avian influenza Birds DNA Epidemiology Genetics Hemagglutinins Hong Kong Humans Influenza A Virus, H5N1Subtype Mice Mutation Pathogenicity Proteins Virology Abstract: From abstract (online abstract only): In 1997, an H5N1 influenza A virus was transmitted from birds to humans in Hong Kong, killing 6 of the 18 people infected. When mice were infected with the human isolates, two virulence groups became apparent. Using reverse genetics, we showed that a mutation at position 627 in the PB2 protein influenced the outcome of infection in mice. Moreover, high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection.
Precursor Genes of Future Pandemic Influenza Viruses Are Perpetuated in Ducks Nesting in Siberia Show Full Record 1401
Source: Archives of Virology. 2000;145(5):885-93 Resource Type(s): Journal (Articles) Searchable Keywords: Animals Avian influenza Comparative studies Disease reservoirs DNA Ducks Genetics Influenza in birds Japan Mice Poultry Proteins Siberia Vaccines Viral genes Viral proteins Virology Abstract: From abstract (online abstract only): Influenza A viruses of different subtypes were isolated from fecal samples of ducks in their nesting areas in Siberia in summer from 1996 to 1998. Phylogenetic analysis of the NP genes of the isolates in Siberia and those in Hokkaido, Japan on their flyway of migration from Siberia to the south in autumn revealed that they belong to the Eurasian lineage of avian influenza viruses. It is noted that the genes of the isolates in Siberia are closely related to t...
Structure and Receptor Specificity of the Hemagglutinin from an H5N1 Influenza Virus Show Full Record 1905
Source: Science. 2006 Apr 21;312(5772):404-10. Epub 2006 Mar 16. Resource Type(s): Journal (Articles) Searchable Keywords: Amino acid sequence Animals Antigenic variation Avian influenza Binding sites Birds Chemistry Glycosylation Hemagglutinins Humans Influenza A Virus, H5N1Subtype Metabolism Molecular structure Pathogenicity Proteins Species specificity Virulence Abstract: From abstract (free full-text available): The hemagglutinin (HA) structure at 2.9 angstrom resolution, from a highly pathogenic Vietnamese H5N1 influenza virus, is more related to the 1918 and other human H1 HAs than to a 1997 duck H5 HA. Glycan microarray analysis of this Viet04 HA reveals an avian alpha2-3 sialic acid receptor binding preference. Introduction of mutations that can convert H1 serotype HAs to human alpha2-6 receptor specificity only enhanced or reduced affinity for avian-type re...
Studies on the Origin of Pandemic Influenza. 3. Evidence Implicating Duck and Equine Influenza Viruses as Possible Progenitors of the Hong Kong Strain of Human Influenza Show Full Record 1894
Source: Virology. 1973 Feb;51(2):383-91. Resource Type(s): Journal (Articles) Searchable Keywords: Amino acid sequence Animals Avian influenza Cross reactions Ducks Etiology Genetic recombination Hemagglutinins Hong Kong Horse diseases Horses Humans Immunodiffusion Orthomyxoviridae Peptides Poultry diseases Proteins Abstract: From abstract (online abstract only): Two strains of influenza virus isolated from horses and ducks in 1963, A/equine/Miami/1/63 (Heq2 Neq2) and A/duck/Ukraine/1/63 (Hav7 Neq2) were found to possess hemagglutinin subunits which cross-reacted in hemagglutination-inhibition and immunodiffusion tests with those of the Hong Kong strain of human influenza A/Hong Kong/1/68 (H3 N2). Peptide maps of the heavy polypeptide chains from the hemagglutinin subunits of these three strains showed a number of... |
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