In the 2012 President's Budget Request, the National Biological Information Infrastructure (NBII) is terminated. As a result, all resources, databases, tools, and applications within this web site will be removed on January 15, 2012. For more information, please refer to the NBII Program Termination page.
Since the early 1950's, laboratory methods to perform genetic analyses have rapidly advanced. Significant additions include the discovery of the three dimensional structure of DNA, technologies for sequencing and synthesizing DNA, and the development of laboratory reagents and procedures to identify expressed genes. Genetic analysis used to rely on the indirect correlation of
genotype
with
phenotype
(morphological characteristics). Now we can directly understand genotype at the molecular level.
The NBII Program is administered by the Biological Informatics Program of the U.S. Geological Survey