Osteoarthritis: Weakness From Inflammation
This study has been completed.
Sponsor:
Information provided by:
National Institute on Aging (NIA)
ClinicalTrials.gov Identifier:
NCT00104312
First received: February 24, 2005
Last updated: May 28, 2009
Last verified: May 2009
| Tracking Information | |||||
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| First Received Date ICMJE | February 24, 2005 | ||||
| Last Updated Date | May 28, 2009 | ||||
| Start Date ICMJE | April 2001 | ||||
| Primary Completion Date | May 2009 (final data collection date for primary outcome measure) | ||||
| Current Primary Outcome Measures ICMJE | |||||
| Original Primary Outcome Measures ICMJE | |||||
| Change History | Complete list of historical versions of study NCT00104312 on ClinicalTrials.gov Archive Site | ||||
| Current Secondary Outcome Measures ICMJE | |||||
| Original Secondary Outcome Measures ICMJE | |||||
| Current Other Outcome Measures ICMJE | |||||
| Original Other Outcome Measures ICMJE | |||||
| Descriptive Information | |||||
| Brief Title ICMJE | Osteoarthritis: Weakness From Inflammation | ||||
| Official Title ICMJE | Weakness From Inflammation: A Basis of Disability From Knee Osteoarthritis | ||||
| Brief Summary | The purpose of this study is to understand the factors that lead to muscle weakness with arthritis and aging. |
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| Detailed Description | Through this study, we hope to learn about the natural history of knee osteoarthritis and the disability that arises from it. We hope to better understand why people with knee osteoarthritis develop difficulty with mobility (e.g. walking, standing) in hopes of finding a cure. This study requires 1 four-hour visit to Harbor Hospital. The visit involves a physical exam, a DEXA bone density scan, blood and urine testing, knee x-rays, strength testing and a surface electromyography (EMG). Samples of muscle, joint fluid and joint tissue will be collected during your planned surgery. Participation in this study is entirely voluntary. |
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| Study Type ICMJE | Observational | ||||
| Study Design ICMJE | Observational Model: Cohort Time Perspective: Cross-Sectional |
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| Biospecimen | Retention: Samples Without DNA Description: Synovial fluid and tissue blood serum muscle biopsy |
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| Sampling Method | Non-Probability Sample | ||||
| Study Population | Community - Men and women |
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| Condition ICMJE | Osteoarthritis | ||||
| Intervention ICMJE | |||||
| Study Group/Cohort (s) |
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| Publications * |
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* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline. |
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| Recruitment Information | |||||
| Recruitment Status ICMJE | Completed | ||||
| Estimated Enrollment ICMJE | 88 | ||||
| Completion Date | May 2009 | ||||
| Primary Completion Date | May 2009 (final data collection date for primary outcome measure) | ||||
| Eligibility Criteria ICMJE | Inclusion Criteria:
Exclusion Criteria:
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| Gender | Both | ||||
| Ages | 50 Years and older | ||||
| Accepts Healthy Volunteers | No | ||||
| Contacts ICMJE | Contact information is only displayed when the study is recruiting subjects | ||||
| Location Countries ICMJE | United States | ||||
| Administrative Information | |||||
| NCT Number ICMJE | NCT00104312 | ||||
| Other Study ID Numbers ICMJE | AG0016 | ||||
| Has Data Monitoring Committee | |||||
| Responsible Party | Shari Ling, MD, Principal Investigator, National Institute on Aging | ||||
| Study Sponsor ICMJE | National Institute on Aging (NIA) | ||||
| Collaborators ICMJE | |||||
| Investigators ICMJE |
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| Information Provided By | National Institute on Aging (NIA) | ||||
| Verification Date | May 2009 | ||||
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ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP |
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