Marijuana Treatment Project - 3 (MTP-3)

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Mark Litt, University of Connecticut Health Center
ClinicalTrials.gov Identifier:
NCT00107588
First received: April 5, 2005
Last updated: May 10, 2012
Last verified: May 2012

April 5, 2005
May 10, 2012
February 2007
April 2011   (final data collection date for primary outcome measure)
  • Marijuana abstinence [ Time Frame: One-year follow-up period ] [ Designated as safety issue: No ]
  • Self-efficacy, use of coping skills, and treatment attendance [ Time Frame: During 2-month treatment period ] [ Designated as safety issue: No ]
  • Drug use
  • Addiction severity
Complete list of historical versions of study NCT00107588 on ClinicalTrials.gov Archive Site
Continuous abstinence will be predicted by (a) treatment attendance; (b) posttreatment self-efficacy for coping; and (c) use of coping skills [ Time Frame: One-year follow-up period ] [ Designated as safety issue: No ]
Continuous abstinence will be predicted by (a) treatment attendance; (b) posttreatment self-efficacy for coping; and (c) use of coping skills [ Time Frame: One-year follow-up period ]
 
 
 
Marijuana Treatment Project - 3
Contingency Management for Marijuana Dependence

The goal of this research is to improve treatment outcome for marijuana-dependent individuals. The current study builds on the findings of our prior NIDA-funded marijuana treatment study in which improved client outcomes were associated with greater treatment attendance, greater client self-efficacy, and greater use of coping skills. We will use a contingency management paradigm to provide tangible reinforcement for completing homework assignments that are designed to enhance coping skills. It is anticipated that this will result in greater homework compliance, leading to greater self-efficacy regarding one's ability to cope with high-risk situations. Improved self-efficacy will enhance the likelihood of employing coping skills in high-risk situations, thereby increasing the probability of achieving and maintaining abstinence.

Participants will receive an intervention combining one session of motivational enhancement therapy with eight sessions of cognitive-behavioral coping skills therapy (MET+CBT). A contingency management procedure will be added to this intervention, providing reinforcement for completion of homework, as verified by call-ins to an Interactive Voice Recording (IVR) system. Outcomes will be compared to an MET+CBT intervention in which reinforcement will be provided for marijuana-free urine specimens, and to a control group that receives Case Management. Recruitment of 234 marijuana-dependent participants will occur over a three-year period. They will be randomly assigned to one of the three 9-session interventions. Treatment will be individual, manualized, and provided on an outpatient basis. Pretreatment assessments will obtain baseline data; follow-up assessments at three-month intervals for one year will evaluate marijuana use outcomes, other drug or alcohol use, and psychosocial functioning. It is anticipated that the intervention in which completion of homework is reinforced will result in the best outcomes. The mechanisms by which the interventions result in behavior change will be the specific focus of attention in this study.

Interventional
 
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Marijuana Dependence
  • Behavioral: Reinforcement for homework completion
    Provides contingent reinforcement for engaging in homework activities designed to enhance coping skills
  • Behavioral: Reinforcement for Abstinence
    Provides contingent reinforcement for submitting marijuana-free urine specimen
  • Behavioral: Case Management
    Will control for the effect of therapist-client contact by providing supportive case management as an active control condition.
  • Experimental: Reinforcement for homework completion
    Intervention: Behavioral: Reinforcement for homework completion
  • Active Comparator: Reinforcement for Abstinence
    Intervention: Behavioral: Reinforcement for Abstinence
  • Active Comparator: Case Management
    Intervention: Behavioral: Case Management
 

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
234
August 2012
April 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Cannabis dependence
  • Willing to accept random assignment to interventions

Exclusion Criteria:

  • Current dependence on alcohol or other drugs
  • Problems that require inpatient hospitalization
  • Reading ability below fifth grade level
  • Lack of reliable transportation to treatment
  • Excessive commuting distance
Both
18 Years to 80 Years
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00107588
NIDA-12728-06, R01DA012728-06, R01-12728-06
Yes
Mark Litt, University of Connecticut Health Center
University of Connecticut Health Center
National Institute on Drug Abuse (NIDA)
Principal Investigator: Mark D Litt, Ph.D. University of Connecticut Health Center
University of Connecticut Health Center
May 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP