Peggy Hsieh, Ph.D.


GBB
GENOME DYNAMICS SECTION
NIDDK, National Institutes of Health
Building 5 , Room 324
5 Memorial Dr.
Bethesda, MD 20892
Tel: 301-496-0306
Fax: 301-496-9878
Email: ph52x@nih.gov

Peggy Hsieh, Ph.D.

Education / Previous Training and Experience:
B.A., Princeton University, 1979
Ph.D., Massachusetts Institute of Technology, 1983


Research Statement:

Molecular Mechanisms of DNA Repair

The lab’s focus is on molecular and cellular studies of DNA mismatch repair proteins including their roles in post-replication repair, DNA damage signaling, activation of cell cycle and checkpoint controls , and the roles of mismatch repair proteins in homologous recombination and meiosis. Approaches include biochemistry, structural biology, cell biology, and molecular genetics.



Selected Publications:

Geng H, Sakato M, DeRocco V, Yamane K, Du C, Erie DA, Hingorani M, Hsieh P. "Biochemical analysis of the human mismatch repair proteins hMutSα MSH2(G674A)-MSH6 and MSH2-MSH6(T1219D).", J Biol Chem. (13):9777-91. Epub 2012. [Full Text/Abstract]

Geng H, Du C, Chen S, Salerno V, Manfredi C, Hsieh P. "In vitro studies of DNA mismatch repair proteins.", Anal Biochem. (2):179-84. Epub 2011. [Full Text/Abstract]

Diouf B, Cheng Q, Krynetskaia NF, Yang W, Cheok M, Pei D, Fan Y, Cheng C, Krynetskiy EY, Geng H, Chen S, Thierfelder WE, Mullighan CG, Downing JR, Hsieh P, Pui CH, Relling MV, Evans WE. "Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells.", Nat Med. 17(10):1298-303. doi: 10.1038/nm.2430., 2011.[Full Text/Abstract]

Lu, A., Yoshioka, K., Salerno, V., and Hsieh, P. (2008) “The mismatch repair-mediated cell cycle checkpoint response to fluorodeoxyuridine”, J. Cell. Bioch. 105:245-254. [Full Text/Abstract]

Tessmer, I., Yang, Y., Zhai, J., Du, C., Hsieh, P., Hingorani, M. and Erie, D.A. (2008) “Mechanism of MutS searching for DNA mismatches and signaling repair”, J. Biol. Chem. 283:36646-36654. [Full Text/Abstract]

Hsieh, P. and Yamane, K. (2008) “DNA mismatch repair: Molecular mechanism, cancer, and ageing”, Mech Aging Dev 129:391-407. [Full Text/Abstract]

Yoshioka K, Yoshioka Y, Hsieh P ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol Cell (22): 501-10, 2006. [Full Text/Abstract]



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Page last updated: June 28, 2012

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