Constance Tom Noguchi, Ph.D.


LCB
MOLECULAR CELL BIOLOGY SECTION
NIDDK, National Institutes of Health
Building 10 , Room 9N319
10 Center Dr.
Bethesda, MD 20892
Tel: 301-496-1163
Fax: 301-402-0101
Email: cnoguchi@helix.nih.gov

Constance Tom Noguchi, Ph.D.

Education / Previous Training and Experience:
B.A., University of California, Berkeley, 1970
Ph.D., George Washington University, 1975


Research Statement:

The role of cytokines in maintaining stem/progenitor cell characteristics is being investigated. Molecular structure and processing related to cellular function, differentiation, and development are studied using molecular and cell biology, biochemical, and biophysical approaches. Emphasis is on transcriptional regulation and models of proliferation and differentiation including stem cell marking studies and transplantation with particular interest in the function of the erythropoietin receptor and stress response in hematopoietic, neuronal, muscle, endothelial and other stem/progenitor cells. Other studies include differential globin gene expression related to the pathophysiology of sickle cell disease and other hemoglobinopathies.




Selected Publications:

Haley JD Smith DE Schwedes J Brennan R Pearce C Moore C Wang F Petti F Grosveld F Jane SM Noguchi CT Schechter AN  Identification and characterization of mechanistically distinct inducers of gamma-globin transcription.  Biochem Pharmacol (66): 1755-68, 2003. [Full Text/Abstract]

Yu X Shacka JJ Eells JB Suarez-Quian C Przygodzki RM Beleslin-Cokic B Lin CS Nikodem VM Hempstead B Flanders KC Costantini F Noguchi CT  Erythropoietin receptor signalling is required for normal brain development.  Development (129): 505-16, 2002. [Full Text/Abstract]

Yu X Lin CS Costantini F Noguchi CT  The human erythropoietin receptor gene rescues erythropoiesis and developmental defects in the erythropoietin receptor null mouse.  Blood (98): 475-7, 2001. [Full Text/Abstract]

Ogilvie M Yu X Nicolas-Metral V Pulido SM Liu C Ruegg UT Noguchi CT  Erythropoietin stimulates proliferation and interferes with differentiation of myoblasts.  J Biol Chem (275): 39754-61, 2000. [Full Text/Abstract]

Ikonomi P Rivera CE Riordan M Washington G Schechter AN Noguchi CT  Overexpression of GATA-2 inhibits erythroid and promotes megakaryocyte differentiation.  Exp Hematol (28): 1423-31, 2000. [Full Text/Abstract]



Update My page

Page last updated: December 17, 2008

General inquiries may be addressed to:
Office of Communications & Public Liaison
NIDDK, NIH
Bldg 31, Rm 9A06
31 Center Drive, MSC 2560
Bethesda, MD 20892-2560
USA
301.496.3583

The National Institutes of Health   Department of Health and Human Services   USA.gov is the U.S. government's official web portal to all federal, state, and local government web resources and services.  This website is certified by Health On the Net Foundation. Click to verify.