Clinical Research - Diabetes
Clinical research is patient-oriented research. Research may be conducted in human volunteers or on samples from humans. NIH-funded studies are carefully designed to answer specific medical questions while protecting participants' safety. Well conducted clinical trials are the fastest and safest way to find improved treatments and preventions for diseases. Clinical trials or interventional trials determine whether experimental preventions, treatments, or new ways of using known therapies are safe and effective under controlled conditions. Observational or natural history studies examine health issues and disease development in groups of people or populations. The National Library at Medicine explains more about clinical research in Understanding Clinical Trials.
Recruiting
- The Action to Control Cardiovascular Disease Risk in Diabetes (ACCORD)
NIDDK is co-funding a study to test the best ways to lower the risk of heart disease and stroke in adults with type 2 diabetes.
- Bypass Angioplasty Revascularization Investigation (BARI) 2 Diabetes
This study, co-funded by NIDDK, aims to determine the best therapies for people with type 2 diabetes and heart disease.
- Diabetes Research in Children Network (DirecNet)
This clinical center network is researching the potential use of glucose monitoring technology and its impact on the management of type 1 diabetes in children.
- Immune Tolerance Network (ITN)
NIDDK co-funds this international consortium dedicated to evaluating new treatments for autoimmune diseases, asthma, and allergic diseases, and to preventing rejection of transplanted kidneys and pancreatic islets.
- Islet Transplantation Trials for Type 1 Diabetes
Various research centers are performing islet transplantations in a small number of adults with type 1 diabetes.
- SEARCH for Diabetes in Youth Study
This study, co-funded by NIDDK, will determine the prevalence of diabetes in children in six areas of the U.S. and help clarify trends in the development of diabetes in youth.
- TODAY Trial
The TODAY (Treatment Options for type 2 Diabetes in Adolescents andYouth) study, which seeks to identify the best treatment of type 2 diabetes in children and teens, has begun in 12 medical centers and affiliated sites around the country.
- Type 1 Diabetes Special Funding Studies
Several studies are recruiting type 1 diabetes patients (including new-onset patients) and their family members. These studies are supported by a special type 1 diabetes research program.
- Type 1 Diabetes TrialNet
Type 1 Diabetes TrialNet is a network of clinical centers, experts in diabetes and immunology, and specialized laboratories dedicated to testing new approaches to understanding and preventing type 1 diabetes.This clinical research program seeks to prevent type 1 diabetes in high-risk people and to preserve insulin production in those newly diagnosed.
- ClinicalTrials.gov
For other studies in diabetes, search this comprehensive database.
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Ongoing - No Longer Recruiting
Completed
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Follow-up Studies
- Diabetes Prevention Program Outcomes Study (DPPOS)
DPPOS is studying the long term effect of diet and exercise and the diabetes medication, metformin, on the delay of type 2 diabetes in participants of the Diabetes Prevention Program (DPP).
- Epidemiology of Diabetes Interventions and Complications (EDIC) Study
EDIC is studying the long-term complications of type 1 diabetes in participants of the Top
Consortia, Registries, Repositories
- Beta Cell Biology Consortium (BCBC)
The mission of the Beta Cell Biology Consortium (BCBC) is to facilitate interdisciplinary approaches that will advance the understanding of pancreatic islet development and function.
- Collaborative Islet Transplant Registry
The CITR expedites progress and promotes the safety of islet transplantation by collecting, analyzing, and communicating data on islet transplants in the U.S. and Canada.
- Endocrine Pancreas Consortium
The Endocrine Pancreas Consortium was formed in late 1999 to derive and sequence cDNA libraries enriched for rare transcripts expressed in the mammalian endocrine pancreas.
- Environmental Determinants of Diabetes in the Young (TEDDY)
This consortium is organizing international efforts to identify infectious agents, dietary factors, or other environmental factors that trigger type 1 diabetes in genetically susceptible people.
- Genetics of Kidneys in Diabetes (GoKinD)
The purpose of the GoKinD Study is to establish a repository of DNA and clinical information from 1,100 adults with Type 1 diabetes, along with their parents to better understand how genetics contributes to the development of diabetic kidney disease.
- International Type 1 Diabetes Genetics Consortium
This consortium is organizing international efforts to identify genes that determine a person's risk of type 1 diabetes.
- International Type 2 Diabetes Linkage Analysis Consortium
This consortium is organizing international efforts to combine existing data sets for linkage analysis in an effort to map genes for type 2 diabetes. In addition, the availability of a large number of samples allows for analysis of individual ethnic groups for predominant diabetes susceptibility genes.
- Islet Cell Resource Centers
The mission of the Islet Cell Resource Centers (ICRs) is to provide pancreatic islets for basic science studies and clinical trials and to optimize the harvest and shipment of islets while developing tests that characterize the quality and predict the effectiveness of islets transplanted into patients with diabetes mellitus.
- NIDDK Central Repositories
The Biosample, Genetics, and Data Repositories have been established to store biosamples and data collected in designated NIDDK-funded clinical studies. The purpose of the NIDDK Central Repositories is to expand the usefulness of these studies by allowing a wider research community to access these materials beyond the end of the study.
- Type 1 Diabetes Special Funding Program
Information on research funding opportunities, resources, consortia,and networks supported by the Special Funding Program for Type 1 Diabetes Research.
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Last Updated: 11/10/2005
Page last updated: January 01, 0001