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Erythropoiesis and Hemoglobin

The goal of the Erythropoiesis program is to discover the molecular and cellular biological pathways involved in erythroid cell differentiation. This includes not only adult or definitive erythropoiesis (differentiation), but also ontological or primitive erythropoiesis (development).

Specific areas include:

• Transcriptional, post-transcriptional, and translational regulation of erythroid specific genes.
• Mechanisms underlying normal and disordered globin gene regulation.
• Heme biosynthesis and iron metabolism during erythropoiesis.
• Erythroid cell membrane structure and function, and the interaction of transport and receptor molecules.
• Erythropoietin receptor signaling and its effects on gene regulation.
• Mechanistic determinants of red blood cell survival.
• Detection of abnormal hemoglobins.
• Development of genetically targeted therapies for sickle cell anemia and thalassemias.
• Development of clinically applicable approaches for controlling fetal vs. adult b-globin gene expression.

For more information, contact Dr. Terry Rogers Bishop or Dr. Daniel Wright, Program Directors, Hematology Basic Research.

Resources for Researchers Databases, Registries and Information Basic Research Networks Reagents Services Standardization Programs Tissues, Cells, Animals Useful Tools Clinical Research Search for Clinical Trials Centers Centers of Excellence in Molecular Hematology - Overview & Map Related Study Sections Hematology IRG [HEME] Molecular and Cellular Hematology Study Section [MCH] Development-2 Study Section [DEV2] Clinical Hematology Special Emphasis Panel NIDDK Staff Dr. Terry Bishop, Program Director, Hematology Basic Research; Hematology Centers; Hematology Training and Careers Dr. Rebekah Rasooly, Program Director, Genetics and Genomics  Dr. Robert Star, Director, Division of Kidney, Urologic, and Hematologic Diseases Dr. Daniel Wright, Program Director, Hematology Basic Research; Hematology Small Business See Also Hematologic Diseases Health Information Medline Plus: Blood and Blood Disorders

Funding Opportunities All NIDDK PAs, RFAs, and Notices General NIDDK PAs Hematology Research PAs Funding for Special Communities Training and Careers Small Business Conferences Conference Grant Support Upcoming Past Hematologic Diseases Conference Reports Related Reports NIDDK Recent Advances and Emerging Opportunities (2008): Kidney, Urologic, and Hematologic Disease (PDF) Committees and Advisory Groups Kidney, Urologic, and Hematologic Diseases Interagency Coordinating Committee (KUHICC) Related Organizations American Society of Gene Therapy American Society of Hematology American Society of Transplantation American Hemachromatosis Society Cooley's Anemia Foundation

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Page last updated: August 30, 2010