A Study of the Effect of Time on Topical Anesthetic Efficacy.
Recruitment status was Recruiting
Tracking Information | |||||
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First Received Date ICMJE | July 13, 2006 | ||||
Last Updated Date | July 13, 2006 | ||||
Start Date ICMJE | July 2006 | ||||
Primary Completion Date | |||||
Current Primary Outcome Measures ICMJE |
pain | ||||
Original Primary Outcome Measures ICMJE | Same as current | ||||
Change History | No Changes Posted | ||||
Current Secondary Outcome Measures ICMJE |
Heart rate | ||||
Original Secondary Outcome Measures ICMJE | Same as current | ||||
Current Other Outcome Measures ICMJE | |||||
Original Other Outcome Measures ICMJE | |||||
Descriptive Information | |||||
Brief Title ICMJE | A Study of the Effect of Time on Topical Anesthetic Efficacy. | ||||
Official Title ICMJE | A Study of the Effect of Time on Topical Anesthetic Efficacy. | ||||
Brief Summary | This is a study of the effect of time on the effectiveness of topical anesthetics in the mouth. The Null Hypothesis is: Regardless of the time of application over a 10-minute period, there is no difference in the clinical effectiveness of the topical anesthetic 5% lidocaine on (a) the pain of needle stick insertion and (b) the pain of local anaesthetic administration. |
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Detailed Description | The study design will be a double blind randomized controlled split-mouth clinical trial. It is proposed to compare the effectiveness of the standard topical anesthetic 5% lidocaine with a placebo over the time period of 2, 5 and 10 minutes after application. The topical will be placed on the palatal soft tissue where the perception of pain is the highest in the oral cavity. Both the pain of needle insertion and the pain of local anesthetic injection will be compared. |
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Study Type ICMJE | Interventional | ||||
Study Phase | |||||
Study Design ICMJE | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Crossover Assignment Masking: Double-Blind Primary Purpose: Educational/Counseling/Training |
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Condition ICMJE | Pain | ||||
Intervention ICMJE | Drug: lidocaine topical | ||||
Study Arm (s) | |||||
Publications * | |||||
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline. |
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Recruitment Information | |||||
Recruitment Status ICMJE | Recruiting | ||||
Enrollment ICMJE | 90 | ||||
Completion Date | December 2006 | ||||
Primary Completion Date | |||||
Eligibility Criteria ICMJE | Inclusion Criteria:
Exclusion Criteria:
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Gender | Both | ||||
Ages | 18 Years to 70 Years | ||||
Accepts Healthy Volunteers | Yes | ||||
Contacts ICMJE |
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Location Countries ICMJE | Canada | ||||
Administrative Information | |||||
NCT Number ICMJE | NCT00353041 | ||||
Other Study ID Numbers ICMJE | UToronto | ||||
Has Data Monitoring Committee | |||||
Responsible Party | |||||
Study Sponsor ICMJE | University of Toronto | ||||
Collaborators ICMJE | |||||
Investigators ICMJE |
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Information Provided By | University of Toronto | ||||
Verification Date | July 2006 | ||||
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP |