Transcranial Doppler Measurement and Prognosis in Moderate Head Injury
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First Received Date ICMJE | July 17, 2006 | ||||||||
Last Updated Date | November 5, 2008 | ||||||||
Start Date ICMJE | December 2006 | ||||||||
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Change History | Complete list of historical versions of study NCT00353444 on ClinicalTrials.gov Archive Site | ||||||||
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Descriptive Information | |||||||||
Brief Title ICMJE | Transcranial Doppler Measurement and Prognosis in Moderate Head Injury | ||||||||
Official Title ICMJE | Transcranial Doppler Measurement and Prognosis in Moderate Head Injury | ||||||||
Brief Summary | The purpose of this study is to determine whether Transcranial Doppler measurements have correlation with neuropsychological test (Galvestone Orientation Amnesia Test), TC image (Marshall Scale) and prognosis (DRS and GOS) in moderate head injury |
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Detailed Description | The head injury is a frequent problem of health, which produces high morbi-mortality. Today is the main cause of death and disability between 18 and 40 years. In addition it originates expensive expenses in health care systems. Severity of cerebral injury is not only because of impact, it is implicated many physiopathological changes. Decrease or increase of cerebral blood flow (CBF) play important roll formation of edema and intracranial hypertension. Hypoxic/ischemic damage is the final point of both changes. The transcranial Doppler (TCD) was introduced around 1982. Through TCD can be measured the flow velocity of intracranial arteries, which let us identify changes in diameter in vessels. There are three windows of access to arteries: transtemporal, transorbitary and suboccipital. The parameter are systolic velocity (S), tele-diastolic velocity (D), mean velocity (M) and pulsatility index (PI). Many studies have been conducted for evaluate utility in head injury, TCD can identify changes that correlate with alteration in CBF intracranial pressure (ICP). The autoregulatory status is important, TCD with decrement in D and increment in PI could tell us about failure in this issue. An invasive way for estimate cerebral perfusion pressure (CCP) with TCD. The most sensible for fall in is amplitude in FV. However there is more correlation between CPP and PI. Vasospasm can occur post trauma, for identify the Lindegaard ratio (FVcma/FVcia) is useful. The other change, hyperemia, can be demonstrated by continuously increase FV. In post traumatic time is very important identify alterations which could produce ischemia. The measurement of CPP generally is gotten by invasión with ICP determination. In severe head injury has been demonstrated correlation between ICP and PI, strongest for CPP and PI. Other parameters are oligaemia and vasospasm in the first 24 hours correlate poor outcome. Because of the non invasive characteristic and good correlation with physiologic and prognosis, we think it is important evaluate if there are a kind of correlation between amnesia and orientation, prognosis and TCD parameters. |
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Study Type ICMJE | Observational | ||||||||
Study Design ICMJE | Time Perspective: Prospective | ||||||||
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Study Population | |||||||||
Condition ICMJE | Head Injury | ||||||||
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Publications * | |||||||||
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline. |
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Recruitment Information | |||||||||
Recruitment Status ICMJE | Suspended | ||||||||
Enrollment ICMJE | 70 | ||||||||
Completion Date | March 2007 | ||||||||
Primary Completion Date | |||||||||
Eligibility Criteria ICMJE | Inclusion Criteria:
Exclusion Criteria:
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Gender | Both | ||||||||
Ages | 16 Years to 50 Years | ||||||||
Accepts Healthy Volunteers | No | ||||||||
Contacts ICMJE | Contact information is only displayed when the study is recruiting subjects | ||||||||
Location Countries ICMJE | Mexico | ||||||||
Administrative Information | |||||||||
NCT Number ICMJE | NCT00353444 | ||||||||
Other Study ID Numbers ICMJE | 27-07TCDHI | ||||||||
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Responsible Party | |||||||||
Study Sponsor ICMJE | Universidad Autonoma de San Luis Potosí | ||||||||
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Information Provided By | Universidad Autonoma de San Luis Potosí | ||||||||
Verification Date | November 2008 | ||||||||
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP |