Cytokine Gene Polymorphisms in Gastric Diseases
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Recently, cytokine polymorphisms are considered to play an important role in the pathogenesis of peptic ulcer and gastric cancer. We intended to clarify the association between polymorphisms of pro-inflammatory and anti-inflammatory cytokines, and the susceptibility to gastric cancer, gastric ulcer and duodenal ulcer in Japan, and to detect the individuals who have higher risks for gastrointestinal disease development.
Condition | Intervention |
---|---|
Gastric Ulcer Duodenal Ulcer Gastric Cancer |
Procedure: IL-1, TNF-alpha, Il-10 |
Study Type: | Interventional |
Study Design: | Allocation: Randomized Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Diagnostic |
Official Title: | Effects of Pro-Inflammatory and Anti-Inflammatory Cytokine Gene Polymorphism on the Development of Gastric Cancer and Peptic Ulcer in Japanese |
Study Start Date: | January 2000 |
H. pylori infection has close associations with the development of peptic ulcer diseases as well as gastric cancer, gastric adenoma, and gastric MALT lymphoma. The association of the host genetics with the susceptibility to various gastroduodenal disorders has been intensively investigated in the pathogenesis of peptic ulcer and gastric cancer by H. pylori infection .
In chronic active gastritis induced by H. pylori infection, activated neutrophils and mononuclear cells produce several pro-inflammatory and anti-inflammatory cytokines. In fact, levels of pro-inflammatory and anti-inflammatory cytokines are elevated in gastric mucosa infected with H. pylori.
Cytokine polymorphisms are associated with various inflammatory and autoimmune diseases. Recently, cytokine polymorphisms are considered to play an important role in the pathogenesis of peptic ulcer and gastric cancer. However, the roles of the IL-10 polymorphisms on the pathogenesis of H. pylori-related gastric cancer and peptic ulcer have not been fully elucidated.It is unclear whether pro-inflammatory and anti-inflammatory cytokines polymorphisms were associated with pathogenesis of peptic ulcer and gastric cancer in Japan. Then, we intended to clarify the association between polymorphisms of IL-10 and the susceptibility to gastric cancer, gastric ulcer and duodenal ulcer in Japan, and to detect the individuals who have higher risks for gastrointestinal disease development.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
-
Exclusion Criteria:
- patinets without H. pylori
Contact: Mitsushige Sugimoto | +81-53-435-2261 | mitsu@hama-med.ac.jp |
Japan | |
Hamamatsu University School of Medicine | Recruiting |
Hamamatsu, Japan, 431-3192 | |
Contact: Mitsushige Sugimoto +81-53-435-2261 mitsu@hama-med.ac.jp |
Study Chair: | MItsushige Sugimoto | First department of medicine, Hamamatsu University School of medicine |
No publications provided
ClinicalTrials.gov Identifier: | NCT00197470 History of Changes |
Other Study ID Numbers: | Mitsu-001 |
Study First Received: | September 12, 2005 |
Last Updated: | September 12, 2005 |
Health Authority: | Japan: Ministry of Health, Labor and Welfare |
Additional relevant MeSH terms:
Duodenal Ulcer Stomach Neoplasms Stomach Diseases Stomach Ulcer Ulcer Peptic Ulcer Duodenal Diseases Intestinal Diseases |
Gastrointestinal Diseases Digestive System Diseases Gastrointestinal Neoplasms Digestive System Neoplasms Neoplasms by Site Neoplasms Pathologic Processes |
ClinicalTrials.gov processed this record on October 16, 2012