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Low-Dose Endotoxemia and the Acute Phase Response

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2005 by Herlev Hospital.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
Herlev Hospital
ClinicalTrials.gov Identifier:
NCT00197899
First received: September 13, 2005
Last updated: December 12, 2005
Last verified: September 2005
History of Changes
  Purpose

The purpuse of this study is to examine the acute phase respons when different doses of E. Coli Endotoxin is injected in healty volunters.


Condition Intervention
Endotoxemia
Sepsis
 Drug: E. Coli endotoxin

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double-Blind
Primary Purpose: Diagnostic

Resource links provided by NLM:

MedlinePlus related topics: Sepsis
U.S. FDA Resources

Further study details as provided by Herlev Hospital:

Study Start Date: March 2004
Estimated Study Completion Date: January 2005
  Eligibility

Ages Eligible for Study:   18 Years to 40 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria: Healty volunteers -

Exclusion Criteria:

Infection 14 days prior to the trial Regular medication Present and /or former heart disease -

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00197899

Locations
Denmark
Department of Intensive Care
Copenhagen, Copenhagen County, Denmark, 2730
Sponsors and Collaborators
Herlev Hospital
Investigators
Study Chair: Bente K Pedersen, MD, DMSc Department of Infectious Diseases 7641, University Hospital of Copenhagen, H:S Rigshospitalet
Principal Investigator: Dorthe H Olsen, MD Department of Intensive Care, Herlev University Hospital
Study Director: Dorthe H Olsen, DM Department of Intensive Care, Herlev University Hospital
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00197899     History of Changes
Other Study ID Numbers: KA 04015
Study First Received: September 13, 2005
Last Updated: December 12, 2005
Health Authority: Denmark: The Regional Committee on Biomedical Research Ethics

Additional relevant MeSH terms:
Acute-Phase Reaction
Sepsis
Endotoxemia
Inflammation
Pathologic Processes
 Infection
Systemic Inflammatory Response Syndrome
Bacteremia
Toxemia

ClinicalTrials.gov processed this record on October 16, 2012