Combination Chemotherapy Followed By Donor Stem Cell Transplant in Treating Patients With Hemophagocytic Lymphohistiocytosis
Recruitment status was Active, not recruiting
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RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of hemophagocytic lymphohistiocytosis cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more hemophagocytic lymphohistiocytosis cells. A donor stem cell transplant may be able to replace blood-forming cells that were destroyed by chemotherapy. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. Cyclosporine and methotrexate may stop this from happening.
PURPOSE: This phase III trial is studying how well combination chemotherapy followed by a donor stem cell transplant works in treating patients with hemophagocytic lymphohistiocytosis.
Condition | Intervention | Phase |
---|---|---|
Nonneoplastic Condition |
Biological: anti-thymocyte globulin Drug: busulfan Drug: cyclophosphamide Drug: cyclosporine Drug: dexamethasone Drug: etoposide Drug: methotrexate Drug: mycophenolate mofetil Drug: therapeutic hydrocortisone Other: laboratory biomarker analysis Procedure: allogeneic hematopoietic stem cell transplantation Procedure: biopsy |
Phase 3 |
Study Type: | Interventional |
Study Design: | Masking: Open Label Primary Purpose: Treatment |
Official Title: | Hemophagocytic Lymphohistiocytosis |
- Survival [ Designated as safety issue: No ]
Estimated Enrollment: | 288 |
Study Start Date: | March 2006 |
Estimated Primary Completion Date: | November 2010 (Final data collection date for primary outcome measure) |
Ages Eligible for Study: | up to 17 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
Newly diagnosed hemophagocytic lymphohistiocytosis (HLH) meeting 1 of the following criteria*:
- Diagnosis by molecular/genetic methods
Diagnosis by meeting 5 out of 8 of the following criteria:
Clinical criteria:
- Fever
- Splenomegaly
Laboratory criteria:
Cytopenias affecting ≥ 2 of 3 lineages in the peripheral blood, including the following:
- Hemoglobin < 9.0 g/dL (< 10.0 g/dL in infants < 4 weeks of age)
- Platelet count < 100,000/mm^3
- Neutrophil count < 1,000/mm^3
Hypertriglyceridemia and/or hypofibrinogenemia:
- Fasting triglycerides ≥ 3.0 mmol/L (i.e., ≥ 265 mg/dL)
- Fibrinogen ≤ 1.5 g/L
Histopathologic criteria:
Hemophagocytosis in bone marrow, spleen, or lymph nodes
- No evidence of malignancy
New diagnostic criteria:
- Low or absent natural killer (NK) cell activity
- Ferritin ≥ 500 mcg/L
- Soluble CD25 (i.e., soluble interleukin-2 receptor) ≥ 2,400 U/mL NOTE: *Patients who do not meet the diagnostic criteria for HLH but who have a strong clinical suspicion of HLH may be eligible at the discretion of the investigator
- Primary HLH (i.e., familial hemophagocytic lymphohistiocytosis [FLH]) OR secondary HLH (i.e., severe acquired form of HLH)
Acceptable donor meeting 1 of the following criteria:
- HLA-identical related donor
- Matched unrelated donor
- Mismatched unrelated donor
- Familial haploidentical donor
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- No prior cytotoxic treatment for HLH
- No prior cyclosporine treatment for HLH
United Kingdom | |
Birmingham Children's Hospital | |
Birmingham, England, United Kingdom, B4 6NH | |
Institute of Child Health at University of Bristol | |
Bristol, England, United Kingdom, BS2 8AE | |
Addenbrooke's Hospital | |
Cambridge, England, United Kingdom, CB2 2QQ | |
Watford General Hospital | |
Herts, England, United Kingdom, WD18 0HB | |
Leeds Cancer Centre at St. James's University Hospital | |
Leeds, England, United Kingdom, LS9 7TF | |
Royal Liverpool Children's Hospital, Alder Hey | |
Liverpool, England, United Kingdom, L12 2AP | |
Great Ormond Street Hospital for Children | |
London, England, United Kingdom, WC1N 3JH | |
Royal Manchester Children's Hospital | |
Manchester, England, United Kingdom, M27 4HA | |
Children's Hospital - Sheffield | |
Sheffield, England, United Kingdom, S10 2TH | |
Southampton General Hospital | |
Southampton, England, United Kingdom, SO16 6YD | |
Royal Aberdeen Children's Hospital | |
Aberdeen, Scotland, United Kingdom, AB25 2ZG | |
Royal Hospital for Sick Children | |
Edinburgh, Scotland, United Kingdom, EH9 1LF | |
Royal Hospital for Sick Children | |
Glasgow, Scotland, United Kingdom, G3 8SJ |
Study Chair: | Vasanta Nanduri, MD | Watford General Hospital |
Additional Information:
No publications provided
ClinicalTrials.gov Identifier: | NCT00334672 History of Changes |
Other Study ID Numbers: | CDR0000481605, CCLG-LCH-2006-02, EU-20619, UKCCSG-HLH-2004, EUDRACT-2005-002187-28 |
Study First Received: | June 7, 2006 |
Last Updated: | February 13, 2010 |
Health Authority: | United States: Federal Government |
Keywords provided by National Cancer Institute (NCI):
hemophagocytic lymphohistiocytosis |
Additional relevant MeSH terms:
Lymphohistiocytosis, Hemophagocytic Histiocytosis, Non-Langerhans-Cell Histiocytosis Lymphatic Diseases Antilymphocyte Serum Busulfan Cyclophosphamide Cyclosporins Cyclosporine Methotrexate Mycophenolate mofetil Dexamethasone Etoposide Mycophenolic Acid BB 1101 |
Hydrocortisone-17-butyrate Dexamethasone acetate Cortisol succinate Hydrocortisone acetate Hydrocortisone 17-butyrate 21-propionate Hydrocortisone Dexamethasone 21-phosphate Immunosuppressive Agents Immunologic Factors Physiological Effects of Drugs Pharmacologic Actions Antineoplastic Agents, Alkylating Alkylating Agents Molecular Mechanisms of Pharmacological Action Antineoplastic Agents |
ClinicalTrials.gov processed this record on October 16, 2012