Anesthetic and Dilating Gel for Cataract Surgery
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
To prepare the eye for cataract surgery, drugs must be given to the eye to allow for surgery to take place. Traditionally, dilating drops and drops containing NSAIDs (to control inflammation) are given to the patient well in advance of surgery at repeated time intervals. As well, a gel containing lidocaine is applied to the eye just prior to surgery to anesthetize (reduce pain and feeling) in the area of the eye. Although effective, the procedure is time-consuming and costly for nursing staff. Recently, a few hospitals have reported success in mixing the pupil-dilating and NSAID drops with the lidocaine gel, creating an “anesthetic dilating gel”. Although success has been reported, there have been no studies to clearly demonstrate that the “anesthetic dilating gel” is as effective at dilating the pupil and reducing sensitivity of the cornea during surgery than the traditional methods of drops and gel. It is possible that the dilating gel is less effective due to slower diffusion of drugs into the eye. The study will compare the effectiveness of the anesthetic dilating gel with the standard pre-operative pharmacologic regimen for cataract surgery. Stability (maintaining effectiveness over time) and contamination of the study gel will also be assessed. If the dilating gel is shown to be as effective in regards to pupil dilation and corneal anesthesia, while maintaining stability and sterility over time, hospitals can be encouraged to use such a anesthetic dilating gel routinely during pre-operative procedures before cataract surgery.
Condition | Intervention |
---|---|
Cataract |
Drug: Anesthetic Dilating Gel |
Study Type: | Interventional |
Study Design: | Allocation: Non-Randomized Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
Official Title: | Comparison of an Anesthetic and Dilating Gel Cocktail Versus the Standard Pre-Operative Pharmacologic Regimen for Cataract Surgery on Corneal Anesthesia and Pupil Dilation. |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- scheduled for first cataract surgery (i.e., first eye)
Exclusion Criteria:
- previous ocular surgery,
- pseudoexfoliation syndrome,
- diabetes,
- herpetic eye disease,
- posterior synechiae,
- previous uveitis
Canada, Ontario | |
Hotel Dieu Hospital | |
Kingston, Ontario, Canada, K7L 5G2 |
Principal Investigator: | Sherif El-Defrawy, MD PhD FRCSC | Hotel Dieu Hospital, Kingston General Hospital, Queen's University |
No publications provided
ClinicalTrials.gov Identifier: | NCT00335400 History of Changes |
Other Study ID Numbers: | QUEENS-SRE-1 |
Study First Received: | June 8, 2006 |
Last Updated: | June 5, 2007 |
Health Authority: | Canada: Health Canada |
Additional relevant MeSH terms:
Cataract Lens Diseases Eye Diseases Anesthetics Central Nervous System Depressants |
Physiological Effects of Drugs Pharmacologic Actions Central Nervous System Agents Therapeutic Uses |
ClinicalTrials.gov processed this record on October 16, 2012