Epigenetic Regulation of BDNF in Major Depression

• BDNF DNA methylation, histone modification, blood BDNF protein and RNA and BDNF rs6265 gene [ Time Frame: 2 years ] [ Designated as safety issue: Yes ]
  

• the associations between BDNF DNA methylation, histone modification, depressive symptoms, suicidal behavior and antidepressant responses in major depressive patients; the correlation between blood BDNF protein and RNA and BDNF rs6265 gene [ Time Frame: 2 years ] [ Designated as safety issue: Yes ]
  

BDNF (brain-derived neurotrophic factor) had been chosen as a candidate gene for a development of major depression. BDNF had been reported to have an important role on neuronal plasticity, axonal growth and connectivity, and participating in the local response to various types of neuronal stressors. BDNF also influences the differentiation of neurons.

In the past studies, the investigators had found that major depressive women had lower serum BDNF protein levels than healthy controls, and their BDNF levels became significantly increased after antidepressant treatments. In addition, some authors had found that reduced expression of BDNF was noted in postmortem brain of completed suicide subjects. Suicidal major depressive patients also had lower plasma BDNF levels than non-suicidal major depressive patients. These findings suggested that BDNF might play an important role in the suicidal behavior.

However, in past studies, the results did not fully explain why major depressive patients with same genotypes had different clinical expression, including the severity of depression, with/without suicide, and the treatment response. Recently, some papers found that there were relationships between epigenetic regulation, including DNA methylation and histone modification, and psychopathology of major depression. Therefore, we try to investigate the relationships between epigenetic regulation of BDNF and major depression.