Duration of Long-term Immunity After Hepatitis B Virus Immunization
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Purpose
Background:
- The hepatitis B vaccine has been shown to be safe and effective in preventing transmission of the hepatitis B virus. Response rates to the initial three doses of the vaccine are high, with significant or even complete immune response. However, this level has been reported to decline rapidly within the first year and more slowly thereafter. There is little data on the durability and long-term protection provided by the hepatitis B vaccine administered to adults in the United States.
- Vaccinated individuals are believed to be protected against hepatitis B virus infection because of a memory immune response. Even if antibody levels are low, the immune system will still be able to produce enough antibody to neutralize the hepatitis B virus. Therefore, booster doses of the vaccine are not recommended, except for some high-risk individuals such as patients on dialysis. Researchers are interested in determining the durability of the immune response of the hepatitis B vaccine in adults with low or intermediate risk for hepatitis B virus infection.
Objectives:
- To examine the long-term immune status of human immunodeficiency virus (HIV) positive and negative individuals who received the hepatitis B vaccine during adulthood, compared with the immune status of individuals who acquired natural immunity by recovering from acute hepatitis B during adulthood.
Eligibility:
- Individuals at least 18 years of age who were vaccinated against hepatitis B at least 10 years ago.
- Individuals at least 18 years of age who contracted and recovered from acute hepatitis B at least 10 years ago.
- Individuals at least 18 years of age who have well-controlled HIV and were vaccinated against hepatitis B at least 10 years ago.
Design:
- Participants will have a single outpatient study visit and potential follow-up visits as part of this protocol.
- Participants will complete a questionnaire assessing possible risk factors for hepatitis B infection, and will provide blood samples to test for hepatitis B antibodies and other immune system studies.
- Participants will receive a letter or phone call with the results of the blood tests:
- Those who no longer have protective levels of antibody against the hepatitis B virus will be offered a booster dose of the hepatitis B vaccine. To monitor immune response to the booster vaccine, additional study visits will be scheduled at 1 and 3 weeks following the booster.
- Those who have chronic infection with the hepatitis B virus will be advised to follow up with their primary care physician, and may be eligible to participate in ongoing treatment trials for chronic hepatitis B.
- Those who have abnormal blood tests will be referred back to their primary care physician for investigation of the abnormal tests results, and may also be referred to other National Institutes of Health protocols.
- Additional tests will evaluate immune response to the measles, mumps, and rubella (German measles) viruses. Some participants may be advised to have an additional MMR vaccine through their primary care physician.
| Condition |
|---|
|
Hepatitis B |
| Study Type: | Observational |
| Study Design: | Time Perspective: Prospective |
| Official Title: | Duration of Long-Term Immunity After Hepatitis B Virus Immunization |
| Estimated Enrollment: | 250 |
| Study Start Date: | August 2010 |
Hepatitis B vaccine is very effective at preventing infection with the hepatitis B virus (HBV). Several studies have reported on the long-term efficacy of the HBV vaccine and indicate a decline in titers of antibody against hepatitis B surface antigen (anti-HBs) over time. However, most of these studies were performed in persons vaccinated as infants or children. This protocol is designed to examine the long-term immune status of HIV positive and negative individuals who were vaccinated during adulthood, and to compare it to the immune status of individuals who acquired natural immunity by recovering from acute hepatitis B during adulthood. Individuals who lost the vaccine-induced humoral immune response, will be offered a booster vaccination and their immune response to the booster vaccination will be assessed. In this study, we will recruit 150 subjects who were vaccinated secondary to their job-related risk of acquiring HBV infection. An additional 50 subjects who had spontaneously recovered from acute hepatitis B greater than or equal to 10 years ago and 50 patients with well-compensated HIV infection who received HBV vaccine greater than or equal to10 years ago will be enrolled as comparison groups. All subjects will be asked to complete a questionnaire to assess their HBV exposure risk as well as factors that may affect their immune response. Immunological assays include the quantitation of HBV-specific antibodies and the qualitative and quantitative assessment of HBV-specific memory B cells and T cells at the indicated time intervals after vaccination or after recovery from acute hepatitis B. Additional immunological assays include testing for antibody to measles, mumps and rubella (German measles) viruses to compare the longevity of antibody response to these vaccines or natural infection to the antibody response to the hepatitis B vaccine or natural infection. The results of this study will help to answer the question whether a booster vaccination is required and at which time after the primary vaccination course it should be considered.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
INCLUSION CRITERIA:
- Age 18 years or above and < 60 years when the first dose of hepatitis B vaccine was administered
- Male or female
- Vaccination with 3 doses of either plasma-derived or recombinant HBV vaccine within one year
- Vaccinated subjects must be able to provide written documentation indicating the dates of their hepatitis B immunization series. In the absence of written documentation, subjects will be asked to sign a written affidavit obtained either from themselves or their physician stating the date of vaccination accurate to one year and that they did not receive a booster dose to the best of their knowledge.
- For recovered patients, spontaneous recovery from acute hepatitis B must have occurred prior to the year 2000
- Willing and able to provide written, informed consent
Additional Inclusion Criteria for HIV positive cohort
- CD4 count of great than or equal to 250 /mm3 at time of vaccination
- Known HIV infection at time of vaccination
EXCLUSION CRITERIA:
- History of chronic HBV infection
- Incomplete HBV vaccine doses
- Known non-response to an adequate course of hepatitis B vaccine
- Received a booster dose of HBV vaccine
- Current or recent (within the last 1 year) use of immunosuppressive/immuno-modifying agents
- Use of immunosuppressive/immuno-modifying agents at the time of vaccination
- Renal failure with requirement for dialysis
- Anti-HIV positive (Except for HIV positive cohort)
- History of bone marrow or stem cell transplant
- History of organ transplant
- Known underlying immune suppressive condition
- Subjects with clinically significant anemia, hemoglobin < 10g/dL will be excluded from participating in the assessment of response to a booster dose of HBV vaccine until their hemoglobin is greater than or equal to12g/dL.
Contacts and Locations| Contact: Elenita Rivera, R.N. | (301) 496-3531 | erivera@cc.nih.gov |
| Contact: Marc G Ghany, M.D. | (301) 402-5115 | marcg@mail.nih.gov |
| United States, Maryland | |
| National Institutes of Health Clinical Center, 9000 Rockville Pike | Recruiting |
| Bethesda, Maryland, United States, 20892 | |
| Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL) 800-411-1222 ext TTY8664111010 prpl@mail.cc.nih.gov | |
| Principal Investigator: | Marc G Ghany, M.D. | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
More Information
Additional Information:
Publications:
| ClinicalTrials.gov Identifier: | NCT01182311 History of Changes |
| Other Study ID Numbers: | 100187, 10-DK-0187 |
| Study First Received: | August 13, 2010 |
| Last Updated: | May 17, 2012 |
| Health Authority: | United States: Federal Government |
Keywords provided by National Institutes of Health Clinical Center (CC):
|
Hepatitis B Virus Hepatitis B Vaccine Immunity B-Cell Response |
T-Cell Response Hepatitis B Immunity Hepatitis B Virus Vaccine |
Additional relevant MeSH terms:
|
Hepatitis Hepatitis A Hepatitis B Liver Diseases Digestive System Diseases Hepatitis, Viral, Human |
Virus Diseases Enterovirus Infections Picornaviridae Infections RNA Virus Infections Hepadnaviridae Infections DNA Virus Infections |
ClinicalTrials.gov processed this record on October 17, 2012
