Environmental and Genetic Determinants of Nasopharyngeal Carcinoma (NPC)
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Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors in southern China and Southeast Asia. While infection with Epstein-Barr Virus (EBV) is believed to be necessary for the development of NPC, non-viral environmental factors have also been implicated to increase the risk of NPC including consumption of salted fish and other nitrosamine containing preserved foods, formaldehyde and wood dust exposure, and cigarette smoking. In addition to environmental factors, it is widely accepted that genetic susceptibility also plays an important role in the pathogenesis of NPC. Polymorphisms in genes involved in nitrosamine metabolism and DNA repair have been suggested to be associated with NPC risk, and various chromosomal regions linked to NPC development have been reported. These associations highlight the role of both environmental and genomic components in the etiology of NPC.
There is a longstanding history of international collaborative studies to elucidate the role of environmental and genetic factors associated with NPC between investigators in Taiwan and the USA. A case-control study (375 cases; 327 controls) was conducted in the early 1990s, and a large multiplex family study that was completed in 2006 (358 families; 3,216 individuals). Results from these studies have provided some of the most comprehensive epidemiological evidence regarding factors linked to NPC development to date.
As a next logical step, the opportunity now exists to undertake a genome-wide association study of NPC in Taiwan with carefully collected environmental exposure data to systematically examine environmental and genetic factors associated with NPC, and to evaluate gene-gene and gene-environment interactions. The investigators propose a case-control study of 2000 NPC cases (both retrospective [n=800] and prospective [n=1,200]) and 2,000 age-gender-matched hospital controls in northern Taiwan. The study objectives are to: 1) evaluate putative environmental exposures and NPC; 2) assess the effect of genetic factors, including both single nucleotide polymorphism and copy number variation through analysis of both main effect and gene-gene interaction; 3) investigate gene-environment interactions by testing for interactions between significant genome-wide genetic variations and EBV and other identified environmental risk factors; and 4) examine the natural history of EBV infection.
Condition |
---|
Nasopharyngeal Carcinoma |
Study Type: | Observational |
Study Design: | Observational Model: Case Control Time Perspective: Cross-Sectional |
Official Title: | Far Eastern Memorial Hospital |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Probability Sample |
We propose a case-control study of 2000 NPC cases (both retrospective [n=800] and prospective [n=1,200]) and 2,000 age-gender-matched hospital controls in northern Taiwan
Inclusion Criteria:
- Patients diagnosed with NPC
Exclusion Criteria:
- Case group and control group younger than 18 age. Control group, the reasons for hospitalization for the EB virus-related disease
Taiwan | |
Far Eastern Memorial Hospital | Recruiting |
Taipei, Taiwan | |
Contact: Liao Li-Jen (02)8966-7000 ext 2124 deniro@mail2000.com.tw |
No publications provided
Responsible Party: | Li-Jen Liao, Department of Otolaryngology, Far Eastern Memorial Hospital |
ClinicalTrials.gov Identifier: | NCT01182909 History of Changes |
Other Study ID Numbers: | 099046-F |
Study First Received: | August 15, 2010 |
Last Updated: | September 16, 2011 |
Health Authority: | Taiwan: Department of Health |
Keywords provided by Far Eastern Memorial Hospital:
NPC Environmental and Genetic evaluate putative environmental exposures and NPC |
assess the effect of genetic factors investigate gene-environment interactions examine the natural history of EBV infection |
Additional relevant MeSH terms:
Carcinoma Nasopharyngeal Neoplasms Neoplasms, Glandular and Epithelial Neoplasms by Histologic Type Neoplasms Pharyngeal Neoplasms Otorhinolaryngologic Neoplasms |
Head and Neck Neoplasms Neoplasms by Site Nasopharyngeal Diseases Pharyngeal Diseases Stomatognathic Diseases Otorhinolaryngologic Diseases |
ClinicalTrials.gov processed this record on October 17, 2012