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Age Gender Left Ventricular Mass and Cardiac Troponin T

This study has been completed.
Sponsor:
Information provided by:
University of Heidelberg
ClinicalTrials.gov Identifier:
NCT01100710
First received: April 8, 2010
Last updated: NA
Last verified: February 2007
History: No changes posted
  Purpose

The purpose of this study is to determine the influence of functional or anatomic cardiac parameters, age and gender on high sensitivity cTnT (TnThs) levels in healthy individuals.


Condition
Heart Failure

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Relative Contribution of Age, Gender and Left Ventricular Mass as Quantified by Cardiac Magnetic Resonance Tomography to Detectable Levels of Cardiac Troponin T in a Healthy Reference Population Aged Below 70 Years

Resource links provided by NLM:

MedlinePlus related topics: Heart Failure
U.S. FDA Resources

Further study details as provided by University of Heidelberg:

Enrollment: 116
Study Start Date: March 2007
Study Completion Date: December 2009
Primary Completion Date: March 2007 (Final data collection date for primary outcome measure)
Groups/Cohorts
healthy volunteers

Detailed Description:

We sought to investigate the relative contribution of functional or anatomic parameters as assessed by cardiac magnetic resonance tomography (cMRI, 1.5 Tesla), and clinical variables including increasing age and gender on high sensitivity cTnT (TnThs) levels in healthy individuals. Therefore we measured TnThs in serum samples of 120 healthy volunteers aged between 20 and 70 years. All individuals underwent cMRI including stress testing using dobutamine or adenosine.TnThs concentrations were related to cMRI and clinical findings. Partial correlation, as well as linear and hierarchical regression analyses were used to identify independent predictors and their relative contribution for prediction of TnThs values.

  Eligibility

Ages Eligible for Study:   20 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

residents of Heidelberg and urban hinterland

Criteria

Inclusion Criteria:

  • agreement, age > 18 years, men and women

Exclusion Criteria:

  • measurable heart disease, any chronic or acute disease, intake of meds, hypertension, Diabetes
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01100710

Locations
Germany
University Hospital of Heidelberg
Heidelberg, Baden-Würtemberg, Germany, 69120
Sponsors and Collaborators
University of Heidelberg
Investigators
Principal Investigator: Evangelos Giannitsis, Prof.
  More Information

Publications:

Responsible Party: Prof. Dr. med. E. Giannitsis, University Hospital Heidelberg
ClinicalTrials.gov Identifier: NCT01100710     History of Changes
Other Study ID Numbers: UHD
Study First Received: April 8, 2010
Last Updated: April 8, 2010
Health Authority: Germany: Ethics Commission

Keywords provided by University of Heidelberg:
Age Gender left ventricular mass high sensitive Troponin T

Additional relevant MeSH terms:
Heart Failure
Heart Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on October 17, 2012