Effects of Music Intervention on the Brain Development of Preschool Children - Full Text View

Purpose

The purpose of this research study is to learn more about the effects a musical intervention has on typical brain development in preschool-aged children.

Condition
Child Development

Study Type:	Observational
Study Design:	Observational Model: Cohort Time Perspective: Prospective
Official Title:	Effects of Music Intervention on the Brain Development of Preschool Children

Resource links provided by NLM:

MedlinePlus related topics: Child Development Infant and Newborn Development Toddler Development Toddler Health

U.S. FDA Resources

Further study details as provided by Avera McKennan Hospital & University Health Center:

Primary Outcome Measures:

Cortical mantle thickness [ Time Frame: 5 months ] [ Designated as safety issue: No ]
Measure cortical mantle thickness in unsedated preschool-age children with an initial magnetic resonance imaging (MRI) scan and compare to measured cortical mantle thickness after a second MRI scan in the same children after 5 months

Secondary Outcome Measures:

Hippocampal volume [ Time Frame: 5 months ] [ Designated as safety issue: No ]
Measure hippocampal volumes in unsedated preschool-age children with an initial MRI scan and compare hippocampal volumes in the same children with a second MRI scan after 5 months

Enrollment:	34
Study Start Date:	December 2010
Study Completion Date:	June 2011
Primary Completion Date:	June 2011 (Final data collection date for primary outcome measure)

Groups/Cohorts
Intervention children Children who are receiving a Suzuki-like violin instruction through their participation in an Early Childhood/Headstart preschool program
Control Group Preschool-age children who are not receiving Suzuki-like violin instruction

Detailed Description:

This study will advance the science on brain research in young children by determining the effects of a musical intervention or training on children's brain development. The study will investigate how regular instruction in the Suzuki-like method of violin affects brain structure and function over the course of approximately five (5) months in preschool-aged children participating in an Early Childhood/Headstart preschool program when compared to a control group of their peers.

Eligibility

Ages Eligible for Study:	3 Years to 5 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

Participants in this research project will be involved with a different research project (Avera Family Wellness Program) investigating the effects of a family-based wellness approach to addressing emotional-behavioral needs of preschool-age children and their families. The Avera Family Wellness Program (AFWP) consists of a group of children who receive the family-based intervention and a group of control preschool-age children.

Criteria

Inclusion Criteria:

Children who are between the ages of 3 and 4.5 years old and are involved in the intervention arm of the Avera Family Wellness Program
Children who are between the ages of 3 and 4.5 years old and are involved in the control arm of the Avera Family Wellness Program

Exclusion Criteria:

Unable to provide written consent to participate in the research project
Unable to complete the MRI scan

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT01275001

Locations

United States, South Dakota
Avera Research Institute
Sioux Falls, South Dakota, United States, 57105

Sponsors and Collaborators

Avera McKennan Hospital & University Health Center

Investigators

Principal Investigator:

Timothy Soundy, MD

Avera McKennan Hospital & University Health Center

More Information

Additional Information:

Avera Research Institute website This link exits the ClinicalTrials.gov site

Publications:

Ho YC, Cheung MC, Chan AS. Music training improves verbal but not visual memory: cross-sectional and longitudinal explorations in children. Neuropsychology. 2003 Jul;17(3):439-50.

Samson S, Peretz I. Effects of prior exposure on music liking and recognition in patients with temporal lobe lesions. Ann N Y Acad Sci. 2005 Dec;1060:419-28.

Fujioka T, Ross B, Kakigi R, Pantev C, Trainor LJ. One year of musical training affects development of auditory cortical-evoked fields in young children. Brain. 2006 Oct;129(Pt 10):2593-608. Epub 2006 Sep 7.

Peterson BS. Neuroimaging in child and adolescent neuropsychiatric disorders. J Am Acad Child Adolesc Psychiatry. 1995 Dec;34(12):1560-76. Review.

Durston S, Tottenham NT, Thomas KM, Davidson MC, Eigsti IM, Yang Y, Ulug AM, Casey BJ. Differential patterns of striatal activation in young children with and without ADHD. Biol Psychiatry. 2003 May 15;53(10):871-8.

Symms M, Jäger HR, Schmierer K, Yousry TA. A review of structural magnetic resonance neuroimaging. J Neurol Neurosurg Psychiatry. 2004 Sep;75(9):1235-44. Review.

Gogtay N, Giedd JN, Lusk L, Hayashi KM, Greenstein D, Vaituzis AC, Nugent TF 3rd, Herman DH, Clasen LS, Toga AW, Rapoport JL, Thompson PM. Dynamic mapping of human cortical development during childhood through early adulthood. Proc Natl Acad Sci U S A. 2004 May 25;101(21):8174-9. Epub 2004 May 17.

Responsible Party:	Avera McKennan Hospital & University Health Center
ClinicalTrials.gov Identifier:	NCT01275001 History of Changes
Other Study ID Numbers:	AIHBG-1360-MRI
Study First Received:	January 10, 2011
Last Updated:	October 4, 2011
Health Authority:	United States: Institutional Review Board

Keywords provided by Avera McKennan Hospital & University Health Center:

brain
brain development
MRI

preschool children
cortical mantle thickness
hippocampal volume

ClinicalTrials.gov processed this record on October 18, 2012