Mapping Mood in the Subthalamic Nucleus in Parkinson's Disease (PD) (MOOD D)
This study is currently recruiting participants.
Verified November 2011 by Washington University School of Medicine
Sponsor:
Washington University School of Medicine
Collaborator:
Information provided by (Responsible Party):
Washington University School of Medicine
ClinicalTrials.gov Identifier:
NCT00847431
First received: February 17, 2009
Last updated: November 2, 2011
Last verified: November 2011
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Purpose
The goal of this study is to determine the vulnerability of mood-related neurocircuitry in Parkinson Disease (PD) using deep brain stimulation of the subthalamic nucleus (STN DBS).
Condition |
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Parkinson's Disease Depression Anxiety |
Study Type: | Observational |
Study Design: | Observational Model: Case Control Time Perspective: Prospective |
Official Title: | Mapping Mood in the Subthalamic Nucleus in PD |
Resource links provided by NLM:
Genetics Home Reference related topics:
familial paroxysmal nonkinesigenic dyskinesia
Perry syndrome
U.S. FDA Resources
Further study details as provided by Washington University School of Medicine:
Estimated Enrollment: | 103 |
Study Start Date: | December 2008 |
Estimated Study Completion Date: | December 2013 |
Groups/Cohorts |
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STN DBS Group
PD patients with deep brain stimulators in the subthalamic nucleus. Subjects within this group will be placed into either a 1 contact group, or 2 contact group, depending on contact location requirements for this study.
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Control Group
PD patients without deep brain stimulator surgery, with similar symptoms to the study group.
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Eligibility
Ages Eligible for Study: | 40 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Study Population
PD patients with and without STN DBS
Criteria
Inclusion Criteria for STN-DBS subjects:
- Age 40 or older
- DBS STN Surgery in past 2 to 36 months
- Ability to tolerate turning off Stimulators
- Ability to read and comprehend questions
- English speaking
Exclusion Criteria for STN-DBS subjects:
- Other severe complications post surgery: stroke, seizure, major loss of consciousness, other brain trauma/surgery, or head injuries(i.e. near drowning), encephalitis, or hydrocephalus, blindness, deafness
- Clinically determined Dementia ( Most recent MMSE score of >24)
Inclusion Criteria for Control subject:
- Age 40 or older
- Ability to read and comprehend questions
- English speaking
Exclusion Criteria for Control subject:
- Other severe complications post surgery: stroke, seizure, major loss of consciousness, other brain trauma/surgery, or head injuries(i.e. near drowning), encephalitis, or hydrocephalus, blindness, deafness
- Clinically determined Dementia ( Most recent MMSE score of >24)
- Plans to have DBS STN surgery in the next 24 months
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00847431
Contacts
Contact: Samantha Blankenship, MSW | 314-362-6514 | blankenships@npg.wustl.edu |
Locations
United States, Missouri | |
Washington University School of Medicine | Recruiting |
St. Louis, Missouri, United States, 63110 | |
Contact: Samantha Blankenship, MSW 314-362-6514 blankenships@npg.wustl.edu | |
Principal Investigator: Tamara G Hershey, PhD | |
United States, Ohio | |
University of Cincinnati, Movement Disorder Center | Recruiting |
Cincinnati, Ohio, United States, 45267-0525 | |
Contact: Maureen Gartner, RN, M.Ed. 513-558-0018 gartnem@ucmail.uc.edu | |
Principal Investigator: Fredy Revilla, MD |
Sponsors and Collaborators
Washington University School of Medicine
Investigators
Principal Investigator: | Tamara G Hershey, PhD | Washington University School of Medicine |
More Information
Additional Information:
No publications provided
Keywords provided by Washington University School of Medicine:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 26, 2012
Additional Information:
No publications provided
Responsible Party: | Washington University School of Medicine |
ClinicalTrials.gov Identifier: | NCT00847431 History of Changes |
Other Study ID Numbers: | 08-0354, RO1 NS058797 |
Study First Received: | February 17, 2009 |
Last Updated: | November 2, 2011 |
Health Authority: | United States: Institutional Review Board |
Keywords provided by Washington University School of Medicine:
Subthalamic Nucleus Deep Brain Stimulation Depression Anxiety Parkinson's Disease |
Additional relevant MeSH terms:
Anxiety Disorders Depression Depressive Disorder Parkinson Disease Mental Disorders Behavioral Symptoms Mood Disorders |
Parkinsonian Disorders Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Nervous System Diseases Movement Disorders Neurodegenerative Diseases |
ClinicalTrials.gov processed this record on September 26, 2012