The Effect of Calcium on Fecal Fat and Energy Excretion
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The overall purpose of this study is to examine the effect of calcium on fecal fat and energy excretion.
Condition | Intervention |
---|---|
Obesity |
Other: Dairy calcium |
Study Type: | Interventional |
Study Design: | Allocation: Randomized Intervention Model: Crossover Assignment Masking: Open Label Primary Purpose: Basic Science |
- Fecal fat excretion, fecal energy excretion, calcium excretion, cholesterol
- Vitamin D, changes in lipolyse
Estimated Enrollment: | 15 |
Study Start Date: | August 2007 |
Estimated Study Completion Date: | February 2008 |
Arms | Assigned Interventions |
---|---|
1
Diet with high content of calcium and high content of fat
|
Other: Dairy calcium
Diets with different content of calcium and fat
|
2
Diet with low content of calcium and high content of fat
|
Other: Dairy calcium
Diets with different content of calcium and fat
|
3
Diet with high content of calcium and normal content of fat
|
Other: Dairy calcium
Diets with different content of calcium and fat
|
4
Diet with low content of calcium and normal content of fat
|
Other: Dairy calcium
Diets with different content of calcium and fat
|
5
Diet with high content of calcium fra supplement and high content of fat
|
Other: Dairy calcium
Diets with different content of calcium and fat
|
Detailed Description:
Several reports have found inverse associations between calcium intake and body weight. Few intervention studies have shown that a high calcium diet resulted in a greater body weight loss than a low calcium diet. The mechanism is not clear, but one possible explanation is reduced absorption of fat in the gut, due to formation of insoluble calcium fatty acid soaps or binding of bile acids which impairs the formation of micelles.
The aim of this study is to examined if a high calcium intake from dairy products, in diets high or normal in fat content, have an effect on fecal energy and fat excretion, concentrations of substrates involved in energy metabolism and blood pressure.
Ages Eligible for Study: | 18 Years to 50 Years |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- healthy meals
- BMI 24-31 kg/m2
- age between 18-50 years
Exclusion Criteria:
- donation of blood 6 months before and under the study
- milk allergy, diabetes, hypertension, hyperlipidemia, cronic infectious disease
- use of dietary supplements 3 months before and under the study
- smoking
- elite athletes
- use of medication
Contact: Arne Astrup, Prof. MD | +45 3533 2476 | ast@life.ku.dk |
Denmark | |
Dept. of Human Nutrition, Faculty of Life Sciences, University of Copenhagen | Recruiting |
Frederiksberg, Denmark, 1958 | |
Contact: Arne Astrup, prof. MD +45 3533 2476 ast@life.ku.dk | |
Contact: Janne K Lorenzen, PhD student +45 3533 3632 jakh@life.ku.dk | |
Principal Investigator: Janne K Lorenzen, PhD student |
Principal Investigator: | Janne K Lorenzen, PhD student | Dept. of Human Nutrition, Faculty of Life Sciences, Univerity of Copenhagen |
No publications provided
ClinicalTrials.gov Identifier: | NCT00519909 History of Changes |
Other Study ID Numbers: | H-KF-01-144/02 |
Study First Received: | August 22, 2007 |
Last Updated: | August 22, 2007 |
Health Authority: | Denmark: Ministry of the Interior and Health |
Keywords provided by University of Copenhagen:
dairy products, calcium, fat excretion, energy excretion |
Additional relevant MeSH terms:
Obesity Overnutrition Nutrition Disorders Overweight Body Weight |
Signs and Symptoms Calcium, Dietary Bone Density Conservation Agents Physiological Effects of Drugs Pharmacologic Actions |
ClinicalTrials.gov processed this record on October 17, 2012