Glasgow Asthma and Allergy Study (GLAAS)
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In the past, doctors separated people with asthma into two groups, those with "allergic asthma" (about 2/3rds of people) and those with "non-allergic asthma". These labels are not much used now as the treatments for all people with asthma don't depend on this classification. However, new treatments for asthma may become available and the classification may again become important. It could be useful for clinicians to know how to identify which patients are likely to benefit from particular treatments.
Additionally, some new blood tests are becoming available and some of these might help to categorise the type of asthma people have. What the study hopes to do is to identify patient features which make a diagnosis of "allergic asthma" more likely and to see which new blood tests are most likely to be helpful in confirming this diagnosis.
Condition |
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Asthma Allergy |
Study Type: | Observational |
Study Design: | Observational Model: Cohort Time Perspective: Cross-Sectional |
Official Title: | Cross Sectional Study to Evaluate and Associate Clinical and Laboratory Features of People With Allergic and Non-allergic Asthma |
- Serum periostin level [ Time Frame: 1 day ] [ Designated as safety issue: No ]This is a cross sectional study. Participants will be assessed and tests conducted at a single visit
- skin prick test [ Time Frame: 1 day ] [ Designated as safety issue: No ]
- Serum total IgE [ Time Frame: 1 day ] [ Designated as safety issue: No ]
- Blood eosinophil count [ Time Frame: 1 day ] [ Designated as safety issue: No ]
- Blood neutrophil count [ Time Frame: 1 day ] [ Designated as safety issue: No ]
- Blood CD4 cells that are positive for CRTh2 [ Time Frame: 1 day ] [ Designated as safety issue: No ]
- Blood eosinophils expressing CRTh2 [ Time Frame: 1 day ] [ Designated as safety issue: No ]
- Spirometry [ Time Frame: 1 day ] [ Designated as safety issue: No ]
Estimated Enrollment: | 200 |
Study Start Date: | June 2012 |
Estimated Study Completion Date: | October 2012 |
Estimated Primary Completion Date: | October 2012 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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General asthma population
People with asthma, aged 18 years and over, non smoker, all severities of disease, regardless of treatment, broad inclusion and few exclusion criteria.
|
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
People with asthma, non smoker, aged 18 and over.
Inclusion Criteria:
- Male and female patients aged 18 years old and over with a diagnosis of asthma and having received at least two prescriptions for any asthma medication in the last 12 months, who have signed an informed consent form prior to initiation of any study-related procedure
Exclusion Criteria:
- under 18 years
- current smokers
- unwilling or unable to give informed consent
- a clinical diagnosis of COPD
- a history of anaphylaxis (skin prick test)
- participated in any clinical study in the last 12 months
Contact: John A Haughney, MB ChB | +44 1760 720702 | j.haughney@abdn.ac.uk |
United Kingdom | |
NSHI Ltd | Recruiting |
Dartford, Kent, United Kingdom, DA1 5GA | |
Principal Investigator: John A Haughney, MB ChB |
Principal Investigator: | John A Haughney, MB ChB | NSHI Ltd |
No publications provided
Responsible Party: | National Services for Health Improvement Ltd |
ClinicalTrials.gov Identifier: | NCT01618318 History of Changes |
Other Study ID Numbers: | 12/WS/0049 |
Study First Received: | June 8, 2012 |
Last Updated: | June 12, 2012 |
Health Authority: | United Kingdom: Research Ethics Committee |
Keywords provided by National Services for Health Improvement Ltd:
Asthma Allergy Diagnosis Correlation study |
Additional relevant MeSH terms:
Hypersensitivity Asthma Immune System Diseases Bronchial Diseases Respiratory Tract Diseases |
Lung Diseases, Obstructive Lung Diseases Respiratory Hypersensitivity Hypersensitivity, Immediate |
ClinicalTrials.gov processed this record on October 17, 2012