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2012 Spring CHARGE Investigator Meeting in Reykjavik, Iceland
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2012 Spring CHARGE Investigator Meeting in Reykjavik, Iceland

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Agenda


Wednesday, May 16, 2012 
9:00 a.m.–1:00 p.mAdiposity Working Group Meeting
Host: Ingrid Borecki, Ph.D., Washington University School of Medicine
12:00–6:00 p.m.Registration
2:00–5:00 p.m.Working Group Meetings
2:00 p.m.CHARGE-S Analysis and Bioinformatics Committee:  L. Adrienne Cupples, Ph.D.
3:00 p.m.ReproGEN:  Joanne Murabito, M.D.
 Lipids:  L. Adrienne Cupples, Ph.D.
4:00 p.m.Subclinical: Joshua Bis, Ph.D.
7:00 p.m.Echo: Vasan Ramachandran, M.D.
5:30–6:30 pm.Reykavjik Welcome Reception
Mayor Jon Gnarr
Reykavjik City Hall
7:00–9:00p.m.CHARGE Steering Committee Meeting / Dinner
Lækjarbrekka
  
Thursday, May 17, 2012 
7:00–8:30 a.m.Registration / Continental Breakfast
8:30–8:40 a.m.Welcome
Vilmundur Gudnason, M.D., Ph.D., Icelandic Heart Association
8:40–9:00 a.m.State of CHARGE
Christopher O‘Donnell, M.D., M.P.H., National Heart Lung and Blood Institute, NIH
9:00–10:30 a.m.Session I:  Genealogy
Moderators:
Vilmundur Gudnason, M.D., Ph.D.,  Icelandic Heart Association
Andrew Johnson, Ph.D., National Heart Lung and Blood Institute, NIH
9:00–9:10 a.m.Introduction to the Icelandic Genetic Environment
Vilmundur Gudnason, M.D., Ph.D., Icelandic Heart Association
9:10–9:40 a.m.Leveraging Icelandic Families To Unravel Genetic Risk Loci
Albert Smith, Ph.D., Icelandic Heart Association
9:40–10:00 a.m.Genome-wide Association Analysis in AGES and REFINE Cohorts:
Modeling Relatedness and Missing Data
Johanna Jakobsdottir, Ph.D., Icelandic Heart Association  
10:00–10:20 a.m.Parent of Origin Effects
Hagit Hochner, Ph.D., The Hebrew University-Hadassah Medical Center  (Jerusalem)
10:20–10:50 a.m.Break
10:50 a.m.–12:40 p.m.Session II: Biostatistics
Moderators:
Thor Aspelund, Ph.D., Icelandic Heart Association
Joshua Bis, Ph.D., University of Washington
10:50–11:10 a.m.Common Carotid Intima Media Thickness and Plaque: A Common and Rare
Variant Meta-Analysis of Sequenced Regions SLC17A4 and PIK3CG
Charles White, M.P.H., Boston University
11:10–11:40 a.m.Analysis of Rare Variants Using Exome-sequence Data in a Dutch Isolate
Najaf Amin, Ph.D., Erasmus Medical Center  (Rotterdam)
11:40 a.m.–12:10 p.m.Beyond The Genome: Computational Challenges of Metabolome Analyses
Corneila van Duijn, Ph.D., Erasmus Medical Center  (Rotterdam)
12:10–12:40 p.m.Meta-analysis and Distributed Computing:
What You Can and Can't Do From the Other Side of the World
Thomas Lumley, Ph.D., University of Auckland (New Zealand)
12:40–1:00 p.m.Lunch - Hilton Bistro
1:00–2:00 p.m.Panel Discussion: Future Models of Data Analyses
Moderator:  Bruce Psaty, M.D., Ph.D., University of Washington
Panel:
Vilmundur Gudnason, M.D., Ph.D., Icelandic Heart Association
Corneila van Duijn, Ph.D., Erasmus Medical Center  (Rotterdam)
Christopher O‘Donnell, M.D., M.P.H., National Heart Lung and Blood Institute, NIH
Eric Boerwinkle, Ph.D., University of Texas at Houston
2:00–3:30 p.m.Session III: Systems Genetics
Moderators:
Tamara Harris, M.D., National Institute of Aging, NIH
Jennifer Brody, B.A. University of Washington
2:00–2:30 p.m.Mediation, Instrumental Variables, and Genomics
Invited Speaker: Tyler Vanderweele, Ph.D., Harvard School of Public Health
2:30–3:00 p.m.Tracing Multi-system Failure in Alzheimer´s Disease to Causal Genes
Invited Speaker: Valur Emilsson, Ph.D., Icelandic Heart Association
3:00–3:30 p.m.Resolving the Genetic Basis of Parkinson's Disease: Moving From Locus to Biological Effect
Invited Speaker: Andrew Singleton, Ph.D., National Institute of Aging, NIH
3:30–4:00 p.m.Break
 4:00–4:40 p.m.Working Group Presentations
Moderators:
David Siscovick, M.D., University of Washington
Alanna Morrison, Ph.D., University of Texas at Houston
4:00–4:20 p.m.Protein Working Group Presentation: Discovery and Fine-Mapping of Serum
Protein Loci Using Trans-ethnic Meta-analysis
Andrew Morris, Ph.D., University of Texas Medical School at Houston
Nora Franceschini, M.D., M.P.H., University of North Carolina at Chapel Hill
4:20–4:35 p.m.Gene Expression Working Group Presentation: Meta-analysis of cis- and
trans-acting eQTLs in Whole Blood Samples of Seven CHARGE Cohorts
Harm-Jan Westra, University Medical Center Groningen
4:35–4:50 p.m.Gene Expression Working Group Presentation: Identifying Age and Gender
Associated Gene Expression Profiles In CHARGE Cohorts
Andrew D. Johnson, Ph.D., National Heart, Lung, and Blood Institute, NIH
  
Poster receptionPoster reception
7:30–9:30 p.m.Group Dinner
Viðeyjarstofa, Reykjavik Harbour
  
Friday May 18, 2012 
7:00–8:30 a.m.Registration / Continental Breakfast / Posters
8:30 a.m.–12:00 p.m.Session IV:  Sequencing / Exome Chip
Moderators:
Eric Boerwinkle, Ph.D., University of Texas at Houston
Fernando Rivadeneira, M.D., Ph.D., Erasmus Medical Center  (Rotterdam)
8:30–9:00 a.m.Imputation-based Fine-mapping: Lessons From the MHC
Paul deBakker, Ph.D., Harvard Medical School
9:00–9:50 a.m.Association Studies With Whole Genome Sequencing:  An Example From CHARGE-S Using Lipid Traits
Arend Voorman, B.S., University of Washington
Alanna Morrison, Ph.D., University of Texas at Houston
9:50–10:10 a.m.Diabetes CHARGE Working Group Presentation: Common and Rare Variants in and Near
RS1 Associated With Fasting Insulin in  CHARGE-S Cohorts
James Meigs, M.D., Harvard Medical School
10:10–10:30 a.m.Break
10:30–10:50 a.m.CHARGE Exome Chip Update
Megan Grove, M.S., University of Washington
10:50–11:20 a.m.Guidelines for Exome Chip Analysis
Kenneth Rice, Ph.D., University of Washington
11:20–11:30 a.m.



11:30 a.m.–12:00 p.m.		Awards
Vilmunder Gudnason, M.D., Ph.D., Icelandic Heart Association


CHARGE-S Sequence Variants Associated With Musculoskeletal Phenotypes
Yi-Hsiang Hsu, Sc.D. Harvard Medical School
12:00–1:00 p.m.Lunch
12:00 p.m.Working Group Meetings
  •   Nutrition: Jennifer Nettleton, Ph.D.
  •   Musculoskeletal: Douglas Kiel, M.D., M.P.H.
  •   Exome Chip: Jerome Rotter, M.D.
  •   Ed Attainment: Philipp Koellinger, Ph.D.
  •   Aging and Longevity: Joanne Murabito, M.D., Sc.M.
1:00 p.m.

Working Group Meetings

  • Pharmacogenetics: Bruce Psaty, M.D., Ph.D.
  • CHARGE EKG: Nona Sotoodehnia, M.D.
  • IGF: Robert Kaplan, Ph.D.
  • Renal: Matthias Olden, Ph.D.
  • Gene Expression: Marjolein Peters, Ph.D.
2:00 p.m.Working Group Meetings
  •   Fatty Acid: Rozenn Lemaitre, Ph.D.
  •   Depression: Henning Tiemeier, M.D., Ph.D.
  •   Sex Hormone: Joanne Murabito, M.D., Sc.M.
  •   Hemostasis: Nicholas Smith, Ph.D.
  •   CHARGE AF/PR (GWAS & CHARGE-S): Nona Sotoodehnia, M.D.
3:00 p.m.Working Group Meetings
  • Neurology: Sudha Seshadri, M.D. (2 hours)
  • Inflammation: Behrooz Alizadeh, M.D., Ph.D.
4:00 p.m.Working Group Meeting
  • Diabetes: James Meigs, M.D.
  
Saturday May 19, 2012 
9:00 a.m.– 4:00 p.m.Social Science Working Group Meeting
Host: Philipp Koellinger, Ph.D., Erasmus University (Rotterdam)
Optional (at own expense):  Day trip to Golden Circle

 
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