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Organic Chemical Metrology Group
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Welcome
The Organic Chemical Metrology Group is responsible for developing, critically evaluating, and applying liquid chromatographic, gas chromatographic, and mass spectrometric techniques for the identification and measurement of organic species in a variety of matrices. Efforts are directed toward applications in clinical chemistry, environmental chemistry, food and nutrition, and forensics and homeland security, and include sample types such as tissues and biological fluids, air particulate matter and sediments, foods and dietary supplements, energetic materials, and pure substances (i.e., reference standards). Measurement services are provided through the development of definitive and reference methods, Standard Reference Materials (SRMs), and quality assurance programs. Programs/Projects
Measurements and Standards for Botanical Dietary Supplements— As part of a multi-year interagency agreement among the National Institute of Standards and Technology (NIST), the National Institutes of Health's Office of Dietary Supplements (NIH/ODS), the … Development of NIST Standard Reference Materials for Trace Explosives Detection— As part of a multiyear interagency agreement between NIST and the Office of Standards of the Department of Homeland Security, NIST is developing a series of Standard Reference Materials (SRMs) to … Botanical Oils Containing Omega-3 and Omega-6 Fatty Acids— The Analytical Chemistry Division has developed a collaborative program with the Center for Drug Evaluation and Research (CDER) and the National Institutes of Health's Office of Dietary … Bitter Orange Standard Reference Materials— Three bitter orange-containing Standard Reference Materials have been developed as part of the Analytical Chemistry Division's program to produce SRMs related to dietary supplements. Levels of … Saw Palmetto Dietary Supplement Standard Reference Materials— Two Standard Reference Materials containing saw palmetto, SRM 3250 Serenoa repens (Fruit) and SRM 3251 Serenoa repens Extract, have been developed as part of the Analytical Chemistry … Development of Reference Methods and Reference Materials for Clinical Diagnostic Markers — The accuracy of clinical diagnostic measurements is essential for reliable diagnosis and cost-effective treatment of disease. NIST's involvement in reference methods and reference materials to … Measurement Methods and Standards for Public Safety and Security— Measurements and standards research within the Analytical Chemistry Division related to public safety and security include a diverse group of activities that are driven primarily by the needs of … Development of Serum-Based SRMs to Assess Nutritional Status— A variety of nutrients are essential for normal functioning of the human body, and deficiencies can lead to serious illnesses. Accurate measurement of vitamin levels is therefore essential for … Fatty Acid Methods and Measurements— The Analytical Chemistry Division is working to develop natural-matrix and solution-based SRMs that are characterized for fatty acid composition. The natural-matrix SRMs are intended primarily for … Development of a Standard Reference Material for Metabolites in Plasma — Metabolomics is a relatively new field that builds upon work in genomics and proteomics. Metabolomics can provide a unique perspective on the biochemical status of an organism through broad … Development of Reference Methods and Reference Materials for the Determination of Hormones in Human Serum— Hormones are chemical messengers that regulate many life functions, and deviations from normal levels can indicate serious health problems. Measurement of levels of steroid and/or thyroid hormones … Reference Measurement Procedures and Materials for Creatinine— Chronic kidney disease (CKD) is a growing problem in the U.S., and current estimates suggest that more than 20 million Americans are affected by this disease. If left untreated, kidney disease can … Expression of Stable Isotopically Labeled Proteins for Use as Internal Standards for Mass Spectrometric Quantitation of Clinical Protein Biomarkers— Proteins are of significant interest as potential indicators (biomarkers) of health or disease. Clinical methods employed to measure these analytes are often based on immunological affinity or … Development of Proteomics-Based Methods for Protein Quantification— NIST is developing methods for the quantification of clinically-relevant protein biomarkers by mass spectrometry. Some methods are intended to establish reference measurement procedures for the … Development of Reference Methods and Reference Materials for the Determination of Cardiac Troponin I in Human Serum— Cardiac troponin I (cTnI) is considered the 'gold standard' for the diagnosis of myocardial infarction and the assessment of cardiac damage. Yet this clinical measurement is plagued with … Development of Standard Reference Materials for Vitamins B6 and B12 in Human Serum— Vitamins are essential to normal functioning of the human body because they serve as co-factors for important biological processes. Deficiencies in vitamins B6 and B12 can lead to problems such as … Development of Reference Methods and Reference Materials for Proteins — A number of proteins show promise as potential markers of health or disease, and commercial assays are being developed for these proteins. For example, measurement of the protein cardiac troponin … Multivitamin/Multielement Dietary Supplement SRM— The Analytical Chemistry Division has produced SRM 3280 Multivitamin/Multielement Tablets for use as a control by laboratories making vitamin or element measurements in similar types of dietary … Measurement and Standards to Support Nutrition Labeling— The Analytical Chemistry Division is working to provide food-matrix reference materials to facilitate compliance with nutritional labeling laws, provide traceability for food exports, improve the … Measurements and Standards for Contaminants in Biological (Human) Materials— For the past 25 years NIST has developed a number of biological fluid and tissue Standard Reference Materials (SRMs) primarily for clinically important analytes (e.g., cholesterol, glucose, … SRMs for Contaminants in Air Particulate Matter— In 1997 the U.S. Environmental Protection Agency (EPA) issued new standards for air particulate matter (PM) as part of the national ambient air quality standards, including new regulations for PM … CCQM Activities in the Organic Analysis Working Group— NIST's Analytical Chemistry Division has participated in over 50 Consultative Committee for Amount of Substance - Metrology in Chemistry (CCQM) Organic Analysis Working Group (OAWG) studies … Metrology and Standards for Canine Olfactory Detection of Explosives— As part of a multi-year interagency agreement between the Office of Standards of the Department of Homeland Security and NIST, NIST is developing measurement tools for and providing compositional … Development of Measurements and Standards for Biofuels— With concerns over the limited supply of non-renewable forms of energy, there is growing interest in renewable sources of energy such as biofuels. The change to renewable energy, however, presents … Biodiesel SRM Development—The NIST Analytical Chemistry Division has collaborated with the Brazil National Institute of Metrology, Standardization and Industrial Quality (INMETRO) on the development of the certified … Dietary Supplement Analysis Quality Assurance Program— The National Institute of Standards and Technology (NIST) has established a Dietary Supplement Quality Assurance Program (DSQAP) in collaboration with the National Institutes of Health (NIH) … SRMs for Organic Contaminants in Human Serum, Milk, and Urine—NIST and the Centers for Disease Control and Prevention (CDC) are collaborating to develop seven new SRMs to meet the expanding needs for the measurement of organic contaminants in human fluids: … Novel Stationary Phase Materials in Separation Science Research— Research activities in separation science continue to focus on investigations of the fundamental physical and chemical processes that influence analyte retention in liquid chromatography (LC), as … Molecular Simulation of Stationary Phase Materials in Liquid Chromatography— Molecular simulation models of monomeric and polymeric stationary phases used for liquid chromatography have been employed to investigate the molecular-level structural features that control … Micronutrients Measurement Quality Assurance Program— The Micronutrients Measurement Quality Assurance Program, coordinated by the Analytical Chemistry Division, supports measurement technology for selected fat- and water-soluble vitamins and … International Comparisons— Because of NIST's role as the National Metrology Institute (NMI) in the U.S., the Analytical Chemistry Division's measurement capabilities must be benchmarked against the capabilities of … Interlaboratory Comparison Exercises for Organic Contaminants and Trace Elements in Marine Sediments and Tissues— Three separate interlaboratory comparison exercises for environmental contaminants in marine specimens were administered in 2007/2008 by the Analytical Chemistry Division. The oldest program is … Improving Measurement Quality in Clinical Proteomics— Through collaboration with academic and government institutes, NIST is critically evaluating and attempting to improve measurement quality in clinical mass spectrometric proteomic investigations. … Evaluation of Oleoresin Capsicum (Pepper Spray) Canisters for Chemical Content and Reliability— Aerosol sprays containing oleoresin capsicum, an extract of hot peppers, have been widely used by law enforcement agencies to subdue non-cooperative individuals. Pepper sprays cause incapacitation … Development of Methods for Measurement of Vitamin D in Foods, Fortified Foods, and Dietary Supplements— Vitamin D is a fat-soluble vitamin that is essential for bone health. Vitamin D deficiency is associated with muscle weakness and osteoporosis and can contribute to an increased risk of falls and … Development of an Amino Acid (in Solution) Standard Reference Material— Amino acids are the sequential components of proteins and many are essential to our physiological well-being. Their quantification by the scientific community varies in technique and application. … Development of a Standard Reference Material for Vitamin D in Human Serum— The prevalence of vitamin D deficiency/insufficiency within the general population is an area of concern. Vitamin D status is generally assessed by measuring levels of the metabolite … Development of a Reference Measurement Procedure for C-Reactive Protein in Human Serum— C-reactive protein (CRP) levels in serum or plasma have been used as an indicator of inflammation and infection. Recent evidence also suggests that CRP levels may have value in identifying … Comprehensive Two-Dimensional Gas Chromatography/Time of Flight Mass Spectrometry (GC x GC/TOF-MS)— Although conventional gas chromatography mass spectrometry (GC/MS) provides relatively high efficiency separations, the analysis of some complex, natural-matrix samples may require the use of even … Chromatographic Separation of Unfolded Proteins for Protein Quantification— NIST is developing methods for the quantification of protein biomarkers by mass spectrometry (MS). Stable isotope labeling of proteins/peptides followed by MS analysis allows relative … Chemical Characterization of Nanoparticles— The Analytical Chemistry Division is helping to support nanotechnology research being conducted throughout NIST by developing and applying methods for the chemical compositional characterization … |
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