Jump to main content.


Toluene Diisocyanate (TDI) Action Plan Summary

What chemicals are addressed in the action plan?

This action plan addresses EPA’s review of Toluene Diisocyanate (TDI) and related compounds, CASRNs 101-68-8, 5873-54-1, 2536-05-2, 26447-40-5, 9016-87-9, 17589-24-1, 31107-36-5, and 25686-28-6.

EPA has developed a separate Action Plan for Methylene Diphenyl Diiscyanate (MDI) and its related compounds. TDI is chemically similar to MDI and presents similar hazard and exposure concerns, but is reportedly used in a different range of products.

Why is EPA concerned about these chemicals?

Diisocyanates are well known dermal and inhalation sensitizers in the workplace and have been documented to cause asthma, lung damage, and in severe cases, fatal reactions. Worker exposures are already subject to protective controls in occupational settings, but EPA is concerned about potential health effects that may result from exposures to the consumer or self-employed worker while using products containing uncured TDI and its related polyisocyanates (e.g., spray-applied sealants and coatings) or incidental exposures to the general population while such products are used in or around buildings including homes or schools.

What action is EPA taking?

Based on EPA’s screening-level review of hazard and exposure information, including information from industry indicating uncured TDI and its related polyisocyanates are used only in industrial products and not in consumer products, EPA intends to:

Download the complete Toluene Diisocyanate (TDI) Action Plan (PDF), (16 pp., 67 KB, About PDF)

Access the public comment docket for the Toluene Diisocyanate (TDI) Action Plan (Docket ID EPA-HQ-OPPT-2011-0180) on Regulations.gov.

Read about safer use of spray polyurethane foam.


Local Navigation


Jump to main content.