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IRIS Guidance Documents
- EPA Cancer Guidelines
- EPA Risk Guidelines (Other than Cancer)
- EPA Science Policy Council Guidelines
- NCEA Guidelines for Peer Review
- Other Guidance Documents and Technical Panel Reports
- References Cited in Older Assessment Documents but Superseded by More Recent Guidance
These Guidance documents are listed by date (grouped by type). Many are now available online, but those that are not can be requested by contacting the IRIS Hotline at (202) 566-1676 (phone), (202) 566-1749 (Fax), or hotline.iris@epa.gov (email).
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EPA Cancer Guidelines
- U.S. EPA. 2005. Guidelines for Carcinogen Risk Assessment EPA/630/P-03/001F, Mar 2005.
- U.S. EPA. 2005. Supplemental Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens EPA/630/R-03/003F, Mar 2005.
- U.S. EPA. 1999. Guidelines for Carcinogen Risk Assessment Review draft. NCEA-F-0644, Jul 1999.
- U.S. EPA. 1996. Proposed Guidelines for Carcinogen Risk Assessment (PDF) (143 pp, 649K) EPA/600/P-92/003C, Apr 1996.
- U.S. EPA. 1986. Guidelines for Carcinogen Risk Assessment EPA/630/R-00/004, Sep 1986.
EPA Risk Guidelines (Other than Cancer)
- U.S. EPA. 2000. Supplementary Guidance for Conducting Health Risk Assessment of Chemical Mixtures. EPA/630/R-00/002, Aug 2000.
- U.S. EPA. 1998. Guidelines for Neurotoxicity Risk Assessment EPA/630/R-95/001F, Apr 1998.
- U.S. EPA, 1996. Guidelines for Reproductive Toxicity Risk Assessment EPA/630/R-96/009, Oct 1996.
- U.S. EPA. 1991. Guidelines for Developmental Toxicity Risk Assessment EPA/600/FR-91/001, Dec 1991.
- U.S. EPA. 1987. Risk Assessment Guidelines of 1986. EPA/600/8-87/045, Sep 1987.
- U.S. EPA. 1986. Guidelines for Mutagenicity Risk Assessment EPA/630/R-98/003, Sep 1986.
- U.S. EPA. 1986. Guidelines for the Health Risk Assessment of Chemical Mixtures (PDF) EPA/630/R-98/002, Sep 1986.
EPA Science Policy Council Guidelines
- U.S. EPA. 2006. Science Policy Council Handbook: Peer Review. Third edition. Office of Science Policy, Office of Research and Development, Washington, DC. EPA/100/B-06/002.
- U.S. EPA. 2000. Science Policy Council Handbook: Risk Characterization. Office of Science Policy, Office of Research and Development, Washington, DC. EPA 100-B-00-002.
- U.S. EPA. 2000. Science Policy Council Handbook: Peer Review (PDF) (185 pp, 3.6M). Second edition. Office of Science Policy, Office of Research and Development, Washington, DC. EPA 100-B-00-001
NCEA Guidelines for Peer Review
Other Guidance Documents and Technical Panel Reports
- U.S. EPA. 2012. Benchmark Dose Technical Guidance
- U.S. EPA. 2011. Recommended Use of Body Weight 3/4 as the Default Method in Derivation of the Oral Reference Dose. EPA/100/R11/0001
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Organisation for Economic Co-operation and Development (OECD). 2009. Series on Testing and Assessment, No. 39: Guidance Document on Acute Inhalation Toxicity Testing (PDF) (71 pp, 604K)
- U.S. EPA. 2006. A Framework for Assessing Health Risks of Environmental Exposure to Children (Final). EPA/600/R-05/093F, Sept 2006
- U.S. EPA. 2002. A Review of the Reference Dose and Reference Concentration Processes. EPA/630/P-02/002F, Dec 2002.
- U.S. EPA. 2000. Benchmark Dose Technical Guidance Document (PDF) (96 pp, 830Kb). External Review Draft. EPA/630/R-00/001, Oct 2000.
- U.S. EPA. 1994. Methods for Derivation of Inhalation Reference Concentrations and Application of Inhalation Dosimetry. EPA/600/8-90/066F, Oct 1994.
- U.S. EPA. 1994. Interim policy for particle size and limit concentration issues in inhalation toxicity studies: Notice of availability. Federal Register Notice 59(206): 53799.
- U.S. EPA. 1988. Recommendations for and Documentation of Biological Values for use in Risk Assessment. EPA 600/6-87/008, Feb 1988.
References Cited in Older Assessment Documents but Superseded by More Recent Guidance
- U.S. EPA. 1993. Reference Dose (RfD): Description and Use in Health Risk Assessments Mar 1993.
- U.S. EPA. 1992. EPA's Approach for Assessing the Risks Associated with Chronic Exposures to Carcinogens Jan 1992.