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ifosfamide
A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | Ifomide Iphosphamid iphosphamide Isoendoxan Iso-Endoxan isophosphamide Naxamide | |
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| US brand names: | | Cyfos Ifex Ifosfamidum | |
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| Foreign brand names: | | Holoxan Holoxane IFO-Cell Ifolem Ifomida Ifoxan Mitoxana Tronoxal | |
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| Abbreviations: | | IFF IFO IFX IPP | |
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| Code names: | | Asta Z-4942 MJF-9325 Z-4942 | |
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| Chemical structures: | | 2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide N,3-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide | |
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