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    Cancer Cell. 2012 Aug 14;22(2):139-40.

    Genomic analysis drives tailored therapy in poor risk childhood leukemia.

    Source

    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

    Abstract

    Ph-like acute lymphoblastic leukemia (ALL) is a novel subgroup of high-risk childhood ALL. In this issue of Cancer Cell, Roberts et al. describe the identification of genetic alterations that lead to activated kinase and cytokine receptor signaling in Ph-like ALL and demonstrate that this aberrant signaling can be inhibited effectively.

    Copyright © 2012 Elsevier Inc. All rights reserved.

    PMID:
    22897843
    [PubMed - in process]

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