In real-world setting, anti-smoking aids help

By Kerry Grens

NEW YORK (Reuters Health) - A large new survey across four countries has found that smokers attempting to quit have considerably more success when they use nicotine patches or prescription medications than when they go it alone without anti-smoking aids.

Past research has yielded conflicting evidence on the effectiveness of drug treatments for smoking cessation - they seem to help in clinical trials, but to make less of a difference in real-life settings.

When researchers accounted for differences between those who tried to quit with the help of medications and those who went ‘cold-turkey' - including their respective recollections of past quit attempts - the new study, published in the journal Addiction, found some quitting aids were linked to four- to six-fold higher success rates.

"This study confirms that the positive result seen in clinical trials translates into the real world," said Saul Shiffman, a psychology professor at the University of Pittsburgh, who was not involved in the research.

On the theory that there could be meaningful differences in quit attempts, including whether people even remember every time they resolved to give up cigarettes, researchers surveyed more than 7,400 adult smokers in the U.S., Canada, Australia and the UK.

Karin Kasza, a statistician at Roswell Park Cancer Institute in Buffalo, New York, who led the study, along with her colleagues, then tracked those individuals to see how many had succeeded in staying smoke-free for at least six months.

About 2,200 people used a prescription medication or nicotine replacement therapy, the rest did not.

Among those who used no medication to quit, five percent remained abstinent from cigarettes for six months.

In comparison, 16 percent of nicotine patch users, 15 percent of people who used buproprion - an antidepressant sold as Zyban - and 19 percent of people who used varenicline (Chantix) stayed off cigarettes for six months.

After taking into account factors that could affect people's success, such as how long and how heavily they had smoked, the researchers determined that buproprion and the nicotine patch were each tied to a four-fold increase in quitting success compared with those who used no medications, and varenicline to a nearly six-fold increase.

Eight percent of people who used oral nicotine replacement products, such as gum, stayed abstinent for six months - but statistically, the difference relative to those using no quitting aids was so small it could have been due to chance.

Of the high quit rates among people using drugs or patches, Kasza said that previous studies in real-world settings have not shown as much success, so her findings are not expected.

"But compared to clinical trial results, this is much closer in line with what they found," she told Reuters Health.

Kasza believes the difference between her studies and others is the reliance of this kind of investigation on memory.

Previous research has found that people who do not use medications to help them quit are less likely to remember a failed quit attempt than are people who failed to quit while using medications.

In other words, if you ask people about their past experiences in trying to quit smoking, "if they're without treatment, they forget them. If they're with treatment, they remember them," explained Dr. John Hughes, a professor of psychiatry at the University of Vermont, who was not involved in the new study.

"Since they're now current smokers, they're remembering the (attempts) that failed with treatment and not the ones that failed without," he said.

This would over-represent the times that people failed to quit while using medications, making the drugs appear less helpful.

To get around the problem, Kasza's group asked people at the outset of the study to recall past attempts to quit within the last month, to ensure the memories were fresh.

They also included only abstinence attempts that lasted longer than a day, to exclude less "serious" resolutions to give up cigarettes.

Overall, the researchers found, people who tried to quit without any aids were likely to be younger, have lower incomes, be less addicted to nicotine and have higher confidence in their ability to break the smoking habit than those who used medications.

Hughes, who, like Shiffman, has been a consultant for companies that market smoking-cessation drugs, said the current study is the best to date comparing medication users to non-users in real-world situations because it is large, it includes people from several countries and it takes into account the influence of memory.

The study does not prove that the medications are responsible for the greater success in quitting, but merely that people who use them are more likely to quit.

Shiffman said that based on the number of studies that have found a positive effect from anti-smoking drugs, it is worth it for smokers to give them a try.

"The disappointing reality is that even when people use these medications to help them quit," Kasza said, "relapse is still the norm. It's better than nothing, but it's by no means a magic bullet."

SOURCE: http://bit.ly/Q0U2IC Addiction, online August 14, 2012.

Reuters Health

Page last updated on 05 September 2012