Program Snapshot
The Common Fund’s Molecular Libraries and Imaging program offers biomedical researchers access to the large-scale screening capacity necessary to identify small molecules that can be optimized as chemical probes to study the functions of genes, cells, and biochemical pathways in health and disease. They may also be used by researchers in the public and private sectors to validate new drug targets, which could then move into the drug-development pipeline. Components of the Molecular Libraries program include:
- The Molecular Libraries Probe Production Centers Network (MLPCN)
- PubChem
- Technology Development
NIH Chemical Genomics Center Now Part of NCATS
The NIH Chemical Genomics Center, created through the Molecular Libraries and Imaging program, provides researchers with access to the large-scale screening and chemistry capacity necessary to identify compounds that can be used as chemical probes to validate new therapeutic targets, has a new administrative home in the NIH National Center for Advancing Translational Sciences (NCATS).
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Program Highlights
Teaching Old Drugs New Tricks: Researchers Identify New Uses for a Class of Drugs to Treat Harmful Microbes
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From Bench to Bedside: Therapeutic Candidate Targeting S1P1 Advances in Clinical Trials for Multiple Sclerosis
A compound initially discovered by the NIH Molecular Libraries Probe Production Center at The Scripps Research Institute, which is part of the NIH Common Fund Molecular Libraries Program, has been further developed by Receptos Inc. into a potential therapeutic agent that has successfully transitioned into Phase 2 and 3 clinical trials.
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Molecular Libraries Probe Production Centers Network (MLPCN) pipeline: Assays for the biological research community and compounds from the Molecular Libraries collection are sent to the screening centers which test the compounds for activity in the submitted assays. Information from the assays is deposited in the open access database PubChem and active compounds are further developed into research tools or leads for new drugs.
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