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Activation of Immediate Early Genes By Drugs of Abuse



NIDA Research Monograph, Number 125 [Printed in 1993]

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Table of Contents

Introduction-----1
Reinhard Grzanna and Roger M. Brown

Regulation of Immediate Early Gene Expression-----3
Brent H. Cochran

Everything Activates C-fos- How Can It Matter?-----25
Steven E. Hyman, Barry E. Kosofsky, Tuong V. Nguyen, Bruce M. Cohen, and Michael J. Comb

Immediate Early Genes: Their Involvement in Physiological and Pathological Responses in the Nervous System-----39
Michael O. Hayward, Tom Curran, and James I. Morgan

Immediate Early Gene Activation and Long-Term Changes in Neural Function: A Possible Role in Addiction?-----54
Harold A. Robertson

Acute Effects of Psychomotor Stimulant Drugs on Gene Expression in the Striatum-----72
Ann M. Graybiel

Functional Organization of the Striatum: Relevance to Actions of Psychostimulant Drugs of Abuse-----82
Charles R. Gerfen

Regulation of Neural Gene Expression in Opiate and Cocaine Addiction-----92
Eric J. Nestler, Clare M. Bergson. Xavier Guitart, and Bruce T. Hope

C-Fos and Fos-Related Antigens as Markers for Neuronal Activity: Perspectives From Neuroendocrine Systems-----117
Gloria E. Hoffman, Wen-Sen Lee, M. Susan Smith, Rula Abbud, Michelle M. Roberts, Alan G. Robinson, and Joseph G. Verbalis

Mechanisms of Opioid-Mediated Antinociception: Correlation of Fos Expression and Behavior-----134
Kathleen R. Gogas, Jon D. Levine, and Allan I. Basbaum

The Ontogeny of Immediate Early Gene Response to Cocaine: A Molecular Analysis of the Effects of Cocaine on Developing Rat Brain-----161
Barry E. Kosofsky and Steven E. Hyman

NMDA Receptor Blockade Prevents Translation, but Not Transcription, of the C-fos Gene Following Stimulation With Multiple Extracellular Signals in Cultured Cortical Neurons: Implications for Plasticity and Molecular Memory-----172
Frank R. Sharp, Kinya Hisanaga, and Stephen M. Sagar

Induction and Suppression of Proto-Oncogenes in Rat Striatum After Single or Multiple Treatments With Cocaine or GBR-12909-----181
Michael J. ladaroia, Eric J. Chuang, Choh-Lun Yeung, Yin Hoo, Mayme Silverthorn, Jun Gu, and Gaetano Draisci

List of NIDA Research Monographs-----212




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