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alemtuzumab
A recombinant DNA-derived humanized monoclonal antibody directed against the cell surface glycoprotein CD52. Alemtuzumab is an IgG1 kappa with human variable framework and constant regions, and complementarity-determining regions derived from a rat monoclonal antibody. This agent selectively binds to CD52, thereby triggering a host immune response that results in lysis of CD52 + cells. CD52 is a glycoprotein expressed on the surface of essentially all normal and malignant B and T cells, a majority of monocytes, macrophages and natural killer (NK) cells, a subpopulation of granulocytes, and tissues of the male reproductive system. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | anti-CD52 monoclonal antibody Campath-1H Monoclonal Antibody Campath-1H Monoclonal Antibody CD52 | |
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| US brand name: | | Campath | |
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| Foreign brand name: | | MabCampath | |
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| Abbreviation: | | MoAb CD52 | |
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