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isotretinoin
A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | 13-cis-retinoic acid 13-cis-vitamin A acid cis-retinoic acid isotretinoinum neovitamin A Neovitamin A Acid | |
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| US brand names: | | Accutane Amnesteem Cistane Claravis Sotret | |
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| Foreign brand names: | | Accure Isotrex Isotrexin Oratane Roaccutan Roaccutane Roacutan | |
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| Abbreviation: | | 13-CRA | |
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| Code name: | | Ro 4-3780 | |
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| Chemical structures: | | 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic Acid 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)2cis-4-trans-6-trans-8-trans-nonatetraenoic Acid | |
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