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recombinant interleukin-12
A recombinant form of the endogenous heterodimeric cytokine interleukin-12 with potential antineoplastic activity. Recombinant interleukin-12 binds to and activates its cell-surface receptor, stimulating the production of interferon-gamma (IFN) which, in turn, induces IFN-gamma-inducible protein-10 (IP-10) and so inhibits tumor angiogenesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | cytotoxic lymphocyte maturation factor interleukin-12 natural killer cell stimulatory factor recombinant human interleukin-12 (IL-12) cytokine | |
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| Abbreviation: | | IL-12 | |
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| Code name: | | Ro 24-7472 | |
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