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pirarubicin
An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | Tepirubicin Tetrahydropyranyl-Doxorubicin theprubicin THP THP-Adriamycin THP-Doxorubicin | |
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| Foreign brand names: | | Pinorubicin Theprubicine Therarubicin | |
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| Abbreviations: | | THP-ADM THP-DOX | |
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| Code name: | | 1609RB | |
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| Chemical structures: | | (2"R)-4'-O-Tetrahydropyranyladriamycin (8S,10S)-10-[[3-Amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-3-yl)-alpha-L-lyxo-hexopyranosyl]oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione [8S-[8Alpha,10alpha(S*)]]-10-[[3-amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-2-yl)-alpha-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione 4'-O-Tetrahydropyranyl Doxorubicin | |
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