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rubitecan
A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | 9-nitrocamptothecin 9-nitro-CPT nitrocamptothecin | |
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| US brand names: | | Camptogen Orathecin | |
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| Abbreviation: | | 9-NC | |
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| Code name: | | RFS 2000 | |
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| Chemical structure: | | 9-nitro-20 (S-)camptothecin | |
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