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alitretinoin
An orally- and topically-active naturally-occurring retinoic acid with antineoplastic, chemopreventive, teratogenic, and embryotoxic activities. Alitretinoin binds to and activates nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR); these activated receptors act as transcription factors, regulating gene expression that results in the inhibition of cell proliferation, induction of cell differentiation, and apoptosis of both normal cells and tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonym: | | 9-cis-retinoic acid | |
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| US brand name: | | Panretin | |
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| Foreign brand names: | | Panretyn Panrexin | |
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| Abbreviation: | | 9-CRA | |
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| Acronym: | | 9-cis-RA | |
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| Code names: | | ALRT1057 LGD1057 | |
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| Chemical structures: | | 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic Acid 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-trans-4-trans-6-cis-8-trans-nonatetraenoic Acid | |
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