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melphalan
An orally available phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | alanine nitrogen mustard L-phenylalanine mustard L-Sarcolysin L-sarcolysin phenylalanine mustard L-sarcolysine phenylalanine mustard phenylalanine nitrogen mustard | |
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| US brand name: | | Alkeran | |
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| Foreign brand names: | | Alkerana Melfalan Melphalanum Sarkolysin | |
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| Abbreviation: | | L-PAM | |
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| Code names: | | CB-3025 WR-19813 | |
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| Chemical structures: | | 4-[bis(2-chloroethyl)amino]-L-phenylalanine p-di(chloroethyl)amino-L-phenylalanine | |
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