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gusperimus
A derivative of the antitumor antibiotic spergualin with immunosuppressant activity. Gusperimus inhibits the interleukin-2-stimulated maturation of T cells to the S and G2/M phases and the polarization of the T cells into IFN-gamma-secreting Th1 effector T cells, resulting in the inhibition of growth of activated naive CD4 T cells; this agent may suppress growth of certain T-cell leukemia cell lines. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | deoxyspergualin Deoxyspergualin Hydrochloride Gusperimus Trihydrochloride | |
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| Foreign brand name: | | Spanidin | |
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| Abbreviation: | | DSG | |
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| Code names: | | BMS-181173 BMY-42215-1 NKT-01 | |
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| Chemical structures: | | 15-deoxyspergualin hydrochloride 1-amino-19-guanidino-11-hydroxy-4,9,12-triazanonadecane-10,13-dione 7-{(aminoiminomethyl)amino]-N-[2-[[4-[(3-aminopropyl)amino]butyl]amnio]-1-hydroxy-2-oxoethyl]heptanamide N-[[[4-[(3-Aminopropyl)amino]-butyl]carbamoyl]hydroxymethyl]-7-guanidinoheptanamide | |
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