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thiotepa
A synthetic alkylating agent. Related to nitrogen mustard, thiotepa alkylates and crosslinks DNA, resulting in the inhibition of DNA replication. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | thiophosphamide thiophosphoramide triethylene thiophosphoramide | |
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| US brand names: | | Girostan STEPA TESPA Thiofozil Thioplex Tifosyl | |
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| Foreign brand names: | | Ledertepa Onco Tiotepa Oncotiotepa Tespamin Tespamine Thiotef Tio-TEF | |
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| Abbreviation: | | TSPA | |
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| Code name: | | WR 45312 | |
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| Chemical structures: | | 1,1',1"-phosphinothioylidynetrisaziridine 1,1',1''-phosphinothioyldynetrisaziridine N,N',N''-triethylenethiophosphoramide tris(1-aziridinyl)phosphine sulfide | |
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