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dactinomycin
A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | ACT-D actinomycin C1 actinomycin D actinomycin I1 actinomycin IV actinomycin X 1 actinomycin-[thr-val-pro-sar-meval] AD dactinomycine meractinomycin | |
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| US brand name: | | Cosmegen | |
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| Foreign brand name: | | Lyovac Cosmegen | |
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| Abbreviation: | | DACT | |
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| Chemical structure: | | 2-bis[cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3 | |
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