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medroxyprogesterone
A synthetic derivative of progesterone administered as an acetate salt (medroxyprogesterone acetate) with antiestrogenic activity. As a do all progestins, medroxyprogesterone binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym: | medroxyprogesterone acetate | ||
US brand names: | Curretab Depo-Provera Provera Provera Dosepak | ||
Abbreviation: | MPA | ||
Chemical structures: | (6alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione 17alpha-hydroxy-6alpha-methylprogesterone 6alpha-methyl-17alpha-hydroxyprogesterone 6alpha-methyl-4-pregnen-17alpha-ol-3,20-dione | ||