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laromustine
A sulfonyl hydrazine prodrug with antineoplastic activity. Laromustine releases the DNA chloroethylating agent 90CE after entering the blood stream; 90CE chloroethylates alkylates the 06 position of guanine, resulting in DNA crosslinking, strand breaks, chromosomal aberrations, and disruption of DNA synthesis. Intracellular metabolism of this agent also releases methyl isocyanate which inhibits 06-alkyl-guanine transferase, an enzyme involved with DNA repair. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| US brand names: | | Cloretazine Onrigin | |
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| Code name: | | VNP40101M | |
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| Chemical structures: | | 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylaminocarbonyl)hydrazine 2'-(2-chloroethyl)-N-methyl-1',2'-bis(methylsulfonyl)carbamohydrazide methanesulfonic acid, 1-(2-chloroethyl)-2-[(methylamino)carbonyl]-2- (methylsulfonyl)hydrazide | |
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